Mutchnick M G, Good A E, Barlas N, Goldstein A L
Thymus. 1981 Dec;3(6):377-81.
Peripheral blood "total" and "avid" T-cell rosettes (ER) were enumerated in 35 patients with ankylosing spondylitis (AS). The in vitro effect of thymosin fraction 5 on "avid" ER formation was also determined. "Total" ER numbers, but not proportions, were lower in patients with AS as compared to matched controls, Both the proportion and number of "avid" ER were lower in the patient group. Thymosin induced a significant increase in "avid" ER proportions and numbers in the patient group with no such effect observed in the controls. It is suggested that there are increased numbers of circulating T lymphocytes in patients with AS that can respond to exogenous thymic factors and acquire the capability to form "avid"ER.
对35例强直性脊柱炎（AS）患者的外周血“总”T细胞玫瑰花结（ER）和“亲和性”T细胞玫瑰花结进行了计数。还测定了胸腺素5组分对“亲和性”ER形成的体外作用。与匹配的对照组相比，AS患者的“总”ER数量降低，但比例未降低。患者组中“亲和性”ER的比例和数量均较低。胸腺素使患者组中“亲和性”ER的比例和数量显著增加，而对照组未观察到这种作用。提示AS患者循环T淋巴细胞数量增加，这些细胞能够对外源性胸腺因子作出反应并获得形成“亲和性”ER的能力。
