Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1405-F1408. doi: 10.1152/ajprenal.00350.2019. Epub 2019 Sep 30.
Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes and hypertension, furthering our understanding of insulin signaling and renal Na handling in both normal and diseased states is essential for improving patient treatments and outcomes. The present review is focused on postprandial effects on Na reabsorption in the kidney and the role of the epithelial Na channels as an important channel contributing to insulin-mediated Na reclamation.
胰岛素被认为是肾脏中许多不同通道和转运体的重要调节剂，但它在预防餐后渗透负荷期间钠和体积丢失方面的作用最近才得到验证。随着越来越多的人患有糖尿病和高血压，深入了解正常和患病状态下的胰岛素信号和肾脏钠处理对于改善患者治疗和预后至关重要。本综述重点介绍了餐后对肾脏钠重吸收的影响以及上皮钠通道作为促进胰岛素介导的钠回收的重要通道的作用。
