Department of Chemical, Biological and Macromolecular Sciences, SN Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata-700106, India.
Department of Zoology, Uluberia College, University of Calcutta, Uluberia, Howrah 711315, India.
Biomater Sci. 2019 Nov 1;7(11):4491-4502. doi: 10.1039/c9bm01039d. Epub 2019 Sep 30.
Here, we have compared the behavioral neurotoxicity of a manganese nanoformulation (citrate functionalized MnO nanoparticles; C-MnO NPs) with that of the well-known neurotoxicant, ionic Mn, in an animal model. We found that mice administered with C-MnO NPs showed no signs of a neurobehavioral disorder, but the NPs instead ameliorated Mn-induced neurotoxicity (Parkinson's-like syndrome) through the chelation of excess Mn ions and subsequent reduction of oxidative damage.
在这里，我们比较了一种锰纳米制剂（柠檬酸官能化 MnO 纳米粒子；C-MnO NPs）和已知神经毒物离子锰的行为神经毒性，在动物模型中进行了研究。我们发现，给予 C-MnO NPs 的小鼠没有出现神经行为障碍的迹象，但 NPs 反而通过螯合过量的 Mn 离子和随后减少氧化损伤，改善了 Mn 诱导的神经毒性（帕金森样综合征）。
