Department of Chemical, Biological Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata, 700106, India.
Department of Zoology, Uluberia College, University of Calcutta, Uluberia, Howrah, 711315, India.
Commun Biol. 2023 Jun 16;6(1):647. doi: 10.1038/s42003-023-05023-6.
Recent findings suggest a key role for reactive oxygen species (ROS) in the pathogenesis and progression of ulcerative colitis (UC). Several studies have also highlighted the efficacy of citrate functionalized MnO nanoparticles as redox medicine against a number of ROS-mediated disorders. Here we show that synthesized nanoparticles consisting of chitosan functionalized tri-manganese tetroxide (MnO) can restore redox balance in a mouse model of UC induced by dextran sulfate sodium (DSS). Our in-vitro characterization of the developed nanoparticle confirms critical electronic transitions in the nanoparticle to be important for the redox buffering activity in the animal model. A careful administration of the developed nanoparticle not only reduces inflammatory markers in the animals, but also reduces the mortality rate from the induced disease. This study provides a proof of concept for the use of nanomaterial with synergistic anti-inflammatory and redox buffering capacity to prevent and treat ulcerative colitis.
最近的研究结果表明，活性氧（ROS）在溃疡性结肠炎（UC）的发病机制和进展中起着关键作用。几项研究还强调了柠檬酸盐功能化 MnO 纳米粒子作为氧化还原医学在治疗多种 ROS 介导的疾病方面的疗效。在这里，我们展示了由壳聚糖功能化三氧化锰（MnO）组成的合成纳米粒子可以恢复葡聚糖硫酸钠（DSS）诱导的 UC 小鼠模型中的氧化还原平衡。我们对开发的纳米粒子的体外特性分析证实，纳米粒子中的关键电子跃迁对于动物模型中的氧化还原缓冲活性很重要。谨慎地给予开发的纳米粒子不仅可以降低动物中的炎症标志物，还可以降低诱导疾病的死亡率。这项研究为使用具有协同抗炎和氧化还原缓冲能力的纳米材料来预防和治疗溃疡性结肠炎提供了概念验证。
