Department of Microbiology, The University of Chicago, Chicago, Illinois 60637, USA; email:
Annu Rev Virol. 2019 Sep 29;6(1):319-340. doi: 10.1146/annurev-virology-092818-015748.
Viruses manipulate cellular lipids and membranes at each stage of their life cycle. This includes lipid-receptor interactions, the fusion of viral envelopes with cellular membranes during endocytosis, the reorganization of cellular membranes to form replication compartments, and the envelopment and egress of virions. In addition to the physical interactions with cellular membranes, viruses have evolved to manipulate lipid signaling and metabolism to benefit their replication. This review summarizes the strategies that viruses use to manipulate lipids and membranes at each stage in the viral life cycle.
病毒在其生命周期的每个阶段都操纵细胞脂质和膜。这包括脂质-受体相互作用、病毒包膜与细胞内吞过程中细胞膜的融合、为形成复制隔室而对细胞膜的重排，以及病毒粒子的包膜和出芽。除了与细胞膜的物理相互作用外，病毒还进化出操纵脂质信号和代谢以促进其复制的策略。本文综述了病毒在生命周期的各个阶段操纵脂质和膜的策略。
