Zandi Milad, Mousavi Fatemeh Sadat, Hashemnia Seyyed Mohammed Reza
Iranian Society for Virology, Deputy for Education, Ministry of Health and Medical Education, Tehran, Iran.
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
J Cell Mol Med. 2025 Jan;29(1):e70341. doi: 10.1111/jcmm.70341.
The resurgence of mpox as a global health threat highlights the need to understand its interaction with host cell metabolism. Unlike other well-studied viruses, research on mpox is limited, particularly regarding its impact on cellular processes. In this article, we explore how mpox might manipulate metabolic pathways-such as glycolysis, lipid synthesis and mitochondrial dynamics-to enhance its replication and evade immune responses. By drawing parallels with related poxviruses, we underscore the potential for targeting these metabolic shifts as novel therapeutic strategies. Understanding these interactions is crucial for developing effective treatments against mpox.
猴痘作为一种全球健康威胁的再度出现凸显了了解其与宿主细胞代谢相互作用的必要性。与其他经过充分研究的病毒不同，关于猴痘的研究有限，尤其是在其对细胞过程的影响方面。在本文中，我们探讨了猴痘如何操纵代谢途径，如糖酵解、脂质合成和线粒体动力学，以增强其复制并逃避免疫反应。通过与相关痘病毒进行类比，我们强调了将这些代谢变化作为新型治疗策略的潜力。了解这些相互作用对于开发针对猴痘的有效治疗方法至关重要。
