额颞叶痴呆中紧张症的治疗：来自唑吡坦试验的经验教训。
Treatment of Catatonia in Frontotemporal Dementia: A Lesson From Zolpidem Test.
作者信息
Sayadnasiri Mohammad, Rezvani Farzaneh
机构信息
Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences.
I.R. Social Security Organization, Tehran, Iran.
出版信息
Clin Neuropharmacol. 2019 Sep/Oct;42(5):186-187. doi: 10.1097/WNF.0000000000000362.
BACKGROUND
During recent years, zolpidem presents a potential but transient treatment option for a large variety of neurologic conditions. Although most cases had disorders of consciousness or movement disorders, there are few reports of beneficial effects of zolpidem on language function.
CASE
We present a case of frontotemporal dementia who developed catatonia during her disease course and her refractory speech problem showed dramatic response to zolpidem.
CONCLUSIONS
In dementia patients, different catatonic symptoms may show differential responses to the therapeutic agents and, if verbal symptoms are dominant, it is worthy to try zolpidem in the early stage.
背景
近年来，唑吡坦为多种神经系统疾病提供了一种潜在但短暂的治疗选择。尽管大多数病例存在意识障碍或运动障碍，但关于唑吡坦对语言功能有益影响的报道较少。
病例
我们报告一例额颞叶痴呆患者，在病程中出现紧张症，其难治性言语问题对唑吡坦有显著反应。
结论
在痴呆患者中，不同的紧张症症状对治疗药物可能有不同反应，如果言语症状占主导，在早期尝试使用唑吡坦是值得的。
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