• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

活性氧（ROS）的生理和病理作用：抗氧化治疗的益处和局限性。

Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment.

机构信息

Dipartimento di Biologia, Università di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cinthia, I-80126 Napoli, Italy.

Dipartimento di Scienze e Tecnologie, Università degli Studi di Napoli Parthenope, via Acton n. 38-I-80133 Napoli, Italy.

出版信息

Int J Mol Sci. 2019 Sep 27;20(19):4810. doi: 10.3390/ijms20194810.

DOI:10.3390/ijms20194810
PMID:31569717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6801850/
Abstract

From their discovery in biological systems, reactive oxygen species (ROS) have been considered key players in tissue injury for their capacity to oxidize biological macromolecules [...].

摘要

从其在生物体系中的发现开始，活性氧（ROS）因其氧化生物大分子的能力而被认为是组织损伤的关键因素[...]。

相似文献

1
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment.活性氧（ROS）的生理和病理作用：抗氧化治疗的益处和局限性。
Int J Mol Sci. 2019 Sep 27;20(19):4810. doi: 10.3390/ijms20194810.
2
Role of ROS Production and Turnover in the Antioxidant Activity of Taurine.活性氧的产生与周转在牛磺酸抗氧化活性中的作用。
Adv Exp Med Biol. 2015;803:581-96. doi: 10.1007/978-3-319-15126-7_47.
3
Oxidative stress detection: what for? Part II.氧化应激检测：目的何在？第二部分。
Eur Rev Med Pharmacol Sci. 2007 Jan-Feb;11(1):27-54.
4
Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?抗氧化剂是否会损害活性氧和脂质氧化产物的信号转导？
FEBS Lett. 2012 Nov 2;586(21):3767-70. doi: 10.1016/j.febslet.2012.09.025. Epub 2012 Sep 26.
5
Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor.氧化还原调节与衰老男性生育力及抗氧化剂的作用：救星还是应激源？
Curr Pharm Des. 2017 Nov 28;23(30):4438-4450. doi: 10.2174/1381612822666161019150241.
6
Mitochondria as source of reactive oxygen species under oxidative stress. Study with novel mitochondria-targeted antioxidants--the "Skulachev-ion" derivatives.线粒体作为氧化应激下活性氧的来源。新型线粒体靶向抗氧化剂——“Skulachev 离子”衍生物的研究。
Biochemistry (Mosc). 2010 Feb;75(2):123-9. doi: 10.1134/s000629791002001x.
7
Reactive oxygen species and antioxidants in the pathophysiology of cardiovascular disease: does the actual knowledge justify a clinical approach?活性氧自由基和心血管疾病病理生理学中的抗氧化剂：实际知识是否证明临床方法是合理的？
Curr Vasc Pharmacol. 2010 Mar;8(2):259-75. doi: 10.2174/157016110790887009.
8
Comparison of in vitro tests for antioxidant and immunomodulatory capacities of compounds.比较化合物体外抗氧化和免疫调节能力的试验。
Phytomedicine. 2014 Jan 15;21(2):164-71. doi: 10.1016/j.phymed.2013.08.008. Epub 2013 Sep 14.
9
Importance of oxidative damage on the electron transport chain for the rational use of mitochondria-targeted antioxidants.氧化损伤对电子传递链的重要性及其在线粒体靶向抗氧化剂合理应用中的意义。
Mini Rev Med Chem. 2011 Jun;11(7):625-32. doi: 10.2174/138955711795906879.
10
ROS-related redox regulation and signaling in plants.植物中 ROS 相关的氧化还原调控和信号转导。
Semin Cell Dev Biol. 2018 Aug;80:3-12. doi: 10.1016/j.semcdb.2017.07.013. Epub 2017 Jul 18.

引用本文的文献

1
Antioxidant Effect of a Extract on Intestinal Ischemia/Reperfusion Injury in Rats: A Biochemical and Histological Study.一种提取物对大鼠肠缺血/再灌注损伤的抗氧化作用：一项生化与组织学研究。
Antioxidants (Basel). 2025 May 23;14(6):624. doi: 10.3390/antiox14060624.
2
Counteracting Skin Aging In Vitro by Phytochemicals.植物化学物质在体外对抗皮肤衰老
J Cell Mol Med. 2025 Apr;29(7):e70530. doi: 10.1111/jcmm.70530.
3
Mitochondrial targeted antioxidants as potential therapy for huntington's disease.线粒体靶向抗氧化剂作为亨廷顿病的潜在治疗方法。
Pharmacol Rep. 2024 Aug;76(4):693-713. doi: 10.1007/s43440-024-00619-z. Epub 2024 Jul 9.
4
Application of Nanoparticles: Diagnosis, Therapeutics, and Delivery of Insulin/Anti-Diabetic Drugs to Enhance the Therapeutic Efficacy of Diabetes Mellitus.纳米颗粒的应用：诊断、治疗以及胰岛素/抗糖尿病药物的递送，以提高糖尿病的治疗效果。
Life (Basel). 2022 Dec 11;12(12):2078. doi: 10.3390/life12122078.
5
Normal and Pathological NRF2 Signalling in the Central Nervous System.中枢神经系统中的正常与病理性NRF2信号传导
Antioxidants (Basel). 2022 Jul 22;11(8):1426. doi: 10.3390/antiox11081426.
6
Molecular Evolution of the Activating Transcription Factors Shapes the Adaptive Cellular Responses to Oxidative Stress.激活转录因子的分子进化塑造了细胞对氧化应激的适应性反应。
Oxid Med Cell Longev. 2022 Jul 13;2022:2153996. doi: 10.1155/2022/2153996. eCollection 2022.
7
Selenium Nanoparticles (SeNPs) Immunomodulation Is More Than Redox Improvement: Serum Proteomics and Transcriptomic Analyses.硒纳米颗粒（SeNPs）的免疫调节作用不止于氧化还原改善：血清蛋白质组学和转录组学分析
Antioxidants (Basel). 2022 May 13;11(5):964. doi: 10.3390/antiox11050964.
8
Evaluation of the Cytotoxic Activity of the (L.) F. H. Wigg Dry Extract.评价（L.）F. H. Wigg 干提取物的细胞毒性活性。
Molecules. 2020 Apr 17;25(8):1865. doi: 10.3390/molecules25081865.
9
Rice Gene Improves Drought Tolerance by Modulating Polyamine Biosynthesis Depending on Abscisic Acid and ROS Levels.通过调节多胺生物合成，依赖于脱落酸和 ROS 水平，水稻基因提高耐旱性。
Int J Mol Sci. 2020 Mar 9;21(5):1857. doi: 10.3390/ijms21051857.

本文引用的文献

1
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.线粒体过氧化物酶与活性氧在癌症发生发展中的相互作用。
Int J Mol Sci. 2019 Sep 7;20(18):4407. doi: 10.3390/ijms20184407.
2
Causative Links between Protein Aggregation and Oxidative Stress: A Review.蛋白聚集与氧化应激之间的因果关系：综述。
Int J Mol Sci. 2019 Aug 9;20(16):3896. doi: 10.3390/ijms20163896.
3
Dual Role of Reactive Oxygen Species in Muscle Function: Can Antioxidant Dietary Supplements Counteract Age-Related Sarcopenia?活性氧在肌肉功能中的双重作用：抗氧化膳食补充剂能否对抗与年龄相关的肌肉减少症？
Int J Mol Sci. 2019 Aug 5;20(15):3815. doi: 10.3390/ijms20153815.
4
Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies.谷胱甘肽代谢在肾细胞癌进展中的作用及其治疗意义。
Int J Mol Sci. 2019 Jul 26;20(15):3672. doi: 10.3390/ijms20153672.
5
Carbon Monoxide Releasing Molecule-2-Upregulated ROS-Dependent Heme Oxygenase-1 Axis Suppresses Lipopolysaccharide-Induced Airway Inflammation.一氧化碳释放分子-2 上调活性氧依赖的血红素加氧酶-1 轴抑制脂多糖诱导的气道炎症。
Int J Mol Sci. 2019 Jun 28;20(13):3157. doi: 10.3390/ijms20133157.
6
Trimethylamine N-Oxide Does Not Impact Viability, ROS Production, and Mitochondrial Membrane Potential of Adult Rat Cardiomyocytes.三甲基胺 N-氧化物不会影响成年大鼠心肌细胞的活力、ROS 产生和线粒体膜电位。
Int J Mol Sci. 2019 Jun 21;20(12):3045. doi: 10.3390/ijms20123045.
7
Evolution Shapes the Gene Expression Response to Oxidative Stress.进化塑造了对氧化应激的基因表达反应。
Int J Mol Sci. 2019 Jun 21;20(12):3040. doi: 10.3390/ijms20123040.
8
Mediators of Physical Activity Protection against ROS-Linked Skeletal Muscle Damage.运动防护活性氧相关骨骼肌损伤的中介物。
Int J Mol Sci. 2019 Jun 20;20(12):3024. doi: 10.3390/ijms20123024.
9
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.鞘磷脂合酶 2 通过诱导内质网应激促进血管内皮功能障碍。
Int J Mol Sci. 2019 Jun 12;20(12):2861. doi: 10.3390/ijms20122861.
10
Artemisinin Attenuated Hydrogen Peroxide (HO)-Induced Oxidative Injury in SH-SY5Y and Hippocampal Neurons via the Activation of AMPK Pathway.青蒿素通过激活 AMPK 通路减弱 H2O2 诱导的 SH-SY5Y 和海马神经元氧化损伤。
Int J Mol Sci. 2019 May 31;20(11):2680. doi: 10.3390/ijms20112680.