Koshelev V B, Pinelis V G, Vakulina T P, Markov Kh M, Rodionov I M
Kardiologiia. 1985 Jan;25(1):80-4.
Adaptation to high altitude hypoxia prevents the development of arterial hypertension only in young spontaneously hypertensive rats (SHR) in the pre-hypertension stage. Adult SHR exposed to high altitude hypoxia showed no hypotensive effect. Judging by the experiments with extremities perfusion, the prophylactic effect of high altitude hypoxia in young SHR is associated with an increased number of resistant vessels. The increased ratio of the thickness of the vessel wall to the vascular lumen, however, remains unchanged probably due to the genetically determined development of hypertrophy of vascular smooth muscles.
对高原低氧的适应仅能预防处于高血压前期的年轻自发性高血压大鼠（SHR）发生动脉高血压。暴露于高原低氧环境的成年SHR未显示出降压作用。从肢体灌注实验判断，高原低氧对年轻SHR的预防作用与阻力血管数量增加有关。然而，血管壁厚度与血管腔内径之比增加可能未改变，这可能是由于血管平滑肌肥大的遗传决定发展。
