Meerson F Z, Barbarash N A, Dvurechenskaia G Ia, Prokina N S
Kardiologiia. 1981 Jul;21(7):25-32.
It was shown in experiments on male Wistar rats and rats with spontaneous hereditary hypertension (SHH) that the development of SHH was accompanied by a significant decrease of the renal excretion of water and sodium. The acute hypoxia (the rising in the barochamber to the high altitude of 4400 m during 6 hours) in Wistar rats resulted in a significant decrease of diuresis, glomerular filtration. K and (insignificantly) Na excretion; while in SHH rats acute hypoxia increased diuresis significantly and enhanced the Na and K excretion. The adaptation to hypoxia during 6 hours per day resulted in an increase of diuresis, glomerular filtration, Na excretion and the Na/K coefficient of urine in both the animal lines. During the first month of adaptation the changes were more pronounced in SHH than in Wistar rats, as a result the hypertension did not develop in SHH rats. The relationship of the hypotensive effect of the high altitude adaptation with its natriuretic effect was shown. It is concluded that the natriuretic effect is an important and, probably, the main mechanism of the prophylactic effect of the adaptation to hypoxia on the development of hereditary hypertension.
在对雄性Wistar大鼠和自发性遗传性高血压（SHH）大鼠的实验中发现，SHH的发展伴随着水和钠的肾排泄显著减少。Wistar大鼠的急性缺氧（在气压舱中升至4400米的高海拔6小时）导致利尿、肾小球滤过显著减少，钾以及（不显著地）钠排泄减少；而在SHH大鼠中，急性缺氧显著增加了利尿，并增强了钠和钾的排泄。每天6小时的缺氧适应导致两个品系动物的利尿、肾小球滤过、钠排泄以及尿钠/钾系数增加。在适应的第一个月，SHH大鼠的变化比Wistar大鼠更明显，结果SHH大鼠未发生高血压。研究显示了高海拔适应的降压作用与其利钠作用之间的关系。得出的结论是，利钠作用是缺氧适应对遗传性高血压发展的预防作用的重要且可能是主要机制。
