Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Ottawa, Ontario, Canada; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Ottawa, Ontario, Canada; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Ultrasound Med Biol. 2019 Dec;45(12):3116-3127. doi: 10.1016/j.ultrasmedbio.2019.08.019. Epub 2019 Sep 28.
Although aerobic exercise is recommended as a core component of stroke rehabilitation, knowledge of acute cerebrovascular responses in patients is limited. This study tested the hypothesis that older adults with chronic stroke or cerebral small vessel disease (SVD) exhibit a greater increase in pulsatile hemodynamics during exercise compared with young and age-matched healthy adults. Middle cerebral artery blood flow velocity was acquired during 20 min of moderate intensity cycling in 51 participants from four groups (young, old, SVD and stroke). During rest, only the stroke group had a higher pulsatility index (PI) compared with the young group (1.02 ± 0.17 vs 0.83 ± 0.13; p = 0.038). During exercise, however, the SVD group exhibited a larger increase in PI (68 ± 20% relative to rest) than the young (47 ± 19%), old (45 ± 17%) and stroke (40 ± 25%) groups (p < 0.05, for each). The stress of aerobic exercise may reveal arterial dysfunction associated with latent and overt cerebrovascular disease.
尽管有氧运动被推荐为中风康复的核心组成部分，但人们对患者的急性脑血管反应知之甚少。本研究旨在验证一个假设，即患有慢性中风或脑小血管疾病（SVD）的老年人在运动过程中比年轻和年龄匹配的健康成年人表现出更大的脉动血流动力学变化。在 51 名参与者的四个组（年轻组、老年组、SVD 组和中风组）中，进行 20 分钟的中等强度自行车运动期间，获取大脑中动脉血流速度。在休息时，只有中风组的搏动指数（PI）高于年轻组（1.02 ± 0.17 比 0.83 ± 0.13；p = 0.038）。然而，在运动过程中，SVD 组的 PI 增加幅度（相对于休息时增加 68 ± 20%）明显大于年轻组（增加 47 ± 19%）、老年组（增加 45 ± 17%）和中风组（增加 40 ± 25%）（p < 0.05，每组）。有氧运动的压力可能会揭示与潜在和显性脑血管疾病相关的动脉功能障碍。
