Knight K R, Crabb D J, Niall M, Angus J A, Martin T J, O'Brien B M
Plast Reconstr Surg. 1985 May;75(5):692-702. doi: 10.1097/00006534-198505000-00013.
The rabbit epigastric free flap was used to investigate the effect of prostacyclin and drugs modifying its synthesis in vivo on microvascular blood flow. Prostacyclin and its analogue carbacyclin caused an increase in flow with a maximal twofold increase at approximately 6.5 and 250 ng/ml, respectively, in the flap. Thromboxane synthetase inhibitors such as dazoxiben hydrochloride, UK-38,485, 7-IHA, and imidazole (up to 7 X 10(-4) M in the flap) as well as the prostaglandins 6-oxo-PGF1 alpha and PGE2 (up to 3.7 and 9.2 ng/ml, respectively, in the flap) all failed to modify the control flow rate in the cutaneous microcirculation. It is concluded that the vasodilatory properties of prostacyclin and carbacyclin, together with their known platelet antiaggregatory properties, warrant further study in problem areas of microsurgery such as flap ischemia. The use of thromboxane synthetase inhibitors had no demonstrable effect on the normal flap, and their effect on the ischemic flap remains to be investigated.
采用兔腹壁游离皮瓣研究前列环素及其体内合成修饰药物对微血管血流的影响。前列环素及其类似物卡前列环素可使皮瓣血流量增加，分别在约6.5 ng/ml和250 ng/ml时血流量最大增加两倍。血栓素合成酶抑制剂如盐酸达唑氧苯、UK-38,485、7-IHA和咪唑（皮瓣中浓度高达7×10⁻⁴ M）以及前列腺素6-氧代-PGF1α和PGE2（皮瓣中分别高达3.7 ng/ml和9.2 ng/ml）均未能改变皮肤微循环中的对照流速。得出结论，前列环素和卡前列环素的血管舒张特性及其已知的抗血小板聚集特性，值得在显微外科的问题领域如皮瓣缺血中进一步研究。血栓素合成酶抑制剂对正常皮瓣无明显作用，其对缺血皮瓣的作用仍有待研究。
