血栓素合成酶抑制剂达唑昔本对冷刺激引起的前臂血管收缩及人体血管前列环素生成的影响。
Effects of dazoxiben, an inhibitor of thromboxane synthetase, on forearm vasoconstriction in response to cold stimulation, and on human blood vessel prostacyclin production.
作者信息
Cowley A J, Jones E W, Hanley S P
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):107S-112S. doi: 10.1111/j.1365-2125.1983.tb02118.x.
Abstract
1 In healthy male volunteers dazoxiben (UK 37248), an inhibitor of thromboxane synthetase, abolished the arterial and venous vasoconstriction produced in the forearm by cold stimulation. 2 Aspirin alone had no effect on this vasoconstriction but negated the effect of dazoxiben. 3 In vitro dazoxiben increased the production of prostacyclin by human arteries and veins. 4 By reducing the synthesis of thromboxane A2, a potent vasoconstrictor, and by increasing the synthesis of prostacyclin, a potent vasodilator, dazoxiben may have a therapeutic role in conditions associated with abnormal vasoconstriction.
摘要
- 在健康男性志愿者中，血栓素合成酶抑制剂达唑氧苯（UK 37248）可消除冷刺激在前臂产生的动静脉血管收缩。2. 单独使用阿司匹林对这种血管收缩没有影响，但可抵消达唑氧苯的作用。3. 在体外，达唑氧苯可增加人动脉和静脉中前列环素的生成。4. 通过减少强效血管收缩剂血栓素A2的合成以及增加强效血管舒张剂前列环素的合成，达唑氧苯可能在与异常血管收缩相关的病症中发挥治疗作用。
相似文献
1
Effects of dazoxiben, an inhibitor of thromboxane synthetase, on forearm vasoconstriction in response to cold stimulation, and on human blood vessel prostacyclin production.血栓素合成酶抑制剂达唑昔本对冷刺激引起的前臂血管收缩及人体血管前列环素生成的影响。
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):107S-112S. doi: 10.1111/j.1365-2125.1983.tb02118.x.
2
The effects of dazoxiben, an inhibitor of thromboxane synthetase, on cold-induced forearm vasoconstriction and platelet behaviour in different individuals.
Br J Clin Pharmacol. 1985 Jan;19(1):1-8. doi: 10.1111/j.1365-2125.1985.tb02605.x.
3
A thromboxane synthetase inhibitor in Raynaud's phenomenon.
Prostaglandins Leukot Med. 1983 Sep;12(1):67-71. doi: 10.1016/0262-1746(83)90068-9.
4
Selective inhibition of thromboxane synthetase by dazoxiben increases prostacyclin production by leukocytes in angina patients and healthy volunteers.达唑氧苯对血栓素合成酶的选择性抑制作用可增加心绞痛患者和健康志愿者白细胞中前列环素的生成。
Lancet. 1982 Jul 17;2(8290):164. doi: 10.1016/s0140-6736(82)91137-0.
5
Thromboxane A2 and prostacyclin do not modulate the systemic hemodynamic response to cold in humans.血栓素A2和前列环素不会调节人体对寒冷的全身血流动力学反应。
J Lab Clin Med. 1985 Nov;106(5):534-41.
6
Effects of a thromboxane synthetase inhibitor and a thromboxane antagonist on release and activity of thromboxane A2 and prostacyclin in vitro.血栓素合成酶抑制剂和血栓素拮抗剂对体外血栓素A2和前列环素释放及活性的影响。
Prostaglandins. 1985 May;29(5):785-97. doi: 10.1016/0090-6980(85)90138-8.
7
8
Inhibition of vasoconstrictor mechanisms by dazoxiben in the rat mesenteric vasculature.达唑氧苯对大鼠肠系膜血管收缩机制的抑制作用。
Eur J Pharmacol. 1985 Apr 16;110(3):351-6. doi: 10.1016/0014-2999(85)90563-1.
9
Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581.选择性血栓素合成酶抑制剂OKY 1581对血管壁前列环素的刺激作用。
Prostaglandins Leukot Med. 1983 Sep;12(1):49-52. doi: 10.1016/0262-1746(83)90066-5.
10
Effect of dazoxiben on platelet-vessel wall interaction.达唑氧苯对血小板-血管壁相互作用的影响。
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):45S-46S. doi: 10.1111/j.1365-2125.1983.tb02106.x.
引用本文的文献
1
The effects of dazoxiben, an inhibitor of thromboxane synthetase, on cold-induced forearm vasoconstriction and platelet behaviour in different individuals.
Br J Clin Pharmacol. 1985 Jan;19(1):1-8. doi: 10.1111/j.1365-2125.1985.tb02605.x.
本文引用的文献
1
Methods for the investigation of peripheral blood flow.外周血流的研究方法。
Br Med Bull. 1963 May;19:101-9. doi: 10.1093/oxfordjournals.bmb.a070026.
2
Coronary vasoconstrictor effect of indomethacin in patients with coronary-artery disease.吲哚美辛对冠心病患者的冠状动脉收缩作用。
N Engl J Med. 1981 Nov 12;305(20):1171-5. doi: 10.1056/NEJM198111123052002.
3
Prostacyclin and thromboxane A2 formation in response to adrenergic stimulation in humans: a mechanism for local control of vascular response to sympathetic activation?
Cardiovasc Res. 1981 May;15(5):287-95. doi: 10.1093/cvr/15.5.287.
4
Thromboxane synthetase inhibition as antithrombotic strategy.抑制血栓素合成酶作为抗血栓形成策略。
Lancet. 1981 May 16;1(8229):1073-5. doi: 10.1016/s0140-6736(81)92241-8.
5
Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis.低剂量阿司匹林对人静脉前列环素合成和血小板血栓素合成的差异性抑制作用。
Lancet. 1981 May 2;1(8227):969-71. doi: 10.1016/s0140-6736(81)91733-5.
6
Administration to man of UK-37,248-01, a selective inhibitor of thromboxane synthetase.给人施用UK-37,248-01，一种血栓素合成酶的选择性抑制剂。
Lancet. 1981 Mar 21;1(8221):629-32. doi: 10.1016/s0140-6736(81)91551-8.
7
Effect on forearm arteries and veins of attenuation of the cardiac response to leg exercise.腿部运动时心脏反应减弱对前臂动静脉的影响。
Clin Sci. 1968 Aug;35(1):143-52.
8
Aspirin selectively inhibits prostaglandin production in human platelets.阿司匹林可选择性抑制人体血小板中前列腺素的生成。
Nat New Biol. 1971 Jun 23;231(25):235-7. doi: 10.1038/newbio231235a0.
9
Cardiovascular responses to lower body negative pressure in normal subjects and in patients with diabetes mellitus.正常受试者和糖尿病患者对下体负压的心血管反应。
Cardiovasc Res. 1979 Jan;13(1):31-8. doi: 10.1093/cvr/13.1.31.
10
Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.
Circulation. 1979 Apr;59(4):637-43. doi: 10.1161/01.cir.59.4.637.
Zotero 插件