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本文引用的文献

1
Anesthesia and Brugada syndrome: a 12-year case series.麻醉与布加综合征：一项为期12年的病例系列研究。
J Clin Anesth. 2017 Feb;36:168-173. doi: 10.1016/j.jclinane.2016.09.031. Epub 2016 Dec 7.
2
Is Prevention Better Than Cure?: Local Anesthetics in Brugada Syndrome.预防胜于治疗？：布加综合征中的局部麻醉药。
Reg Anesth Pain Med. 2015 Jul-Aug;40(4):395-6. doi: 10.1097/AAP.0000000000000266.
3
Brugada syndrome--a review of the implications for the anaesthetist.布加综合征——麻醉医师需关注问题的综述
Anaesth Intensive Care. 2011 Jul;39(4):571-7. doi: 10.1177/0310057X1103900406.
4
Anesthetic management of patients with Brugada syndrome: a case series and literature review. Brugada 综合征患者的麻醉管理：病例系列和文献复习。
Can J Anaesth. 2011 Sep;58(9):824-36. doi: 10.1007/s12630-011-9546-y. Epub 2011 Jun 23.
5
Ventricular tachycardia in a patient with Brugada syndrome during general anesthesia combined with thoracic paravertebral block.
Anesth Analg. 2006 May;102(5):1590-1. doi: 10.1213/01.ANE.0000215196.42122.05.
6
Brugada-type electrocardiographic pattern induced by epidural bupivacaine.硬膜外布比卡因诱发的Brugada型心电图模式
Anesth Analg. 2003 Jul;97(1):264-7, table of contents. doi: 10.1213/01.ane.0000067410.32384.3a.
7
Surgically treated primary lung cancer associated with Brugada syndrome: report of a case.手术治疗的原发性肺癌合并Brugada综合征：一例报告
Surg Today. 2001;31(9):817-9. doi: 10.1007/s005950170055.
8
Actions of three local anaesthetics: lidocaine, bupivacaine and ropivacaine on guinea pig papillary muscle sodium channels (Vmax).三种局部麻醉药：利多卡因、布比卡因和罗哌卡因对豚鼠乳头肌钠通道（最大反应速度）的作用。
Pharmacol Toxicol. 1988 Aug;63(2):96-104. doi: 10.1111/j.1600-0773.1988.tb00918.x.

布加综合征患者的肌间沟神经丛阻滞与全身麻醉

Interscalene plexus block and general anesthesia in Brugada syndrome.

作者信息

Ferreira Mónica Nunes, Fontes Sara, Machado Humberto

机构信息

Department of Anesthesiology, Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Portugal.

Department of Anesthesiology, Centro Hospitalar do Porto, Portugal.

出版信息

Saudi J Anaesth. 2019 Oct-Dec;13(4):371-373. doi: 10.4103/sja.SJA_47_19.

DOI:10.4103/sja.SJA_47_19
PMID:31572087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6753764/
Abstract

Brugada syndrome (BrS) is a channelopathy predisposing to malignant ventricular arrhythmias and sudden cardiac death. Perioperative pharmacological and physiological changes may precipitate these events and cardiac dysfunction. We report the efficacy and safety interscalene brachial plexus block combined with general anesthesia in a patient with BrS. Awake and double-guided interscalene block was performed. After performing the block, general anesthesia was induced with fentanyl, propofol and rocuronium and maintained with oxygen-air/sevoflurane mixture. Sugammadex was administered for neuromuscular reversal. During perioperative period, the patient remained hemodynamically stable with anormal sinus rhythm and no ST segment changes. Hospital discharged occurred 36h after surgery without complications. General recommendations include avoidance of increased vagal tone, correction of electrolytes disturbances, maintenance of normothermia, normocapnia, adequate analgesia, and an adequately deep plane of anesthesia. Interscalene block combined with general anesthesia provided good analgesia, hemodynamic and cardiac electric stability.

摘要

Brugada综合征（BrS）是一种易于引发恶性室性心律失常和心源性猝死的离子通道病。围手术期的药理和生理变化可能会促使这些事件和心脏功能障碍的发生。我们报告了在一名BrS患者中肌间沟臂丛神经阻滞联合全身麻醉的有效性和安全性。实施了清醒双引导肌间沟阻滞。阻滞完成后，用芬太尼、丙泊酚和罗库溴铵诱导全身麻醉，并用氧气-空气/七氟醚混合气体维持麻醉。使用舒更葡糖进行神经肌肉阻滞逆转。围手术期，患者血流动力学保持稳定，窦性心律正常，ST段无变化。术后36小时出院，无并发症。一般建议包括避免迷走神经张力增加、纠正电解质紊乱、维持正常体温、正常二氧化碳分压、充分镇痛以及足够深的麻醉平面。肌间沟阻滞联合全身麻醉提供了良好的镇痛效果、血流动力学和心脏电稳定性。