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生存素的反义核酸抑制小鼠宫颈癌生长。

Antisense of survivin inhibits cervical cancer growth in mice.

作者信息

Xu Hui, Liang Tingting, Yang Yongxia, Dong Yanlei, Zhu Lin

机构信息

Department of Gynecology, the Second Hospital, Shandong University, Jinan, China.

出版信息

Arch Med Sci. 2019 Sep;15(5):1345-1351. doi: 10.5114/aoms.2017.71069. Epub 2019 Sep 6.

DOI:10.5114/aoms.2017.71069
PMID:31572483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6764320/
Abstract

INTRODUCTION

It is proposed that survivin plays a critical role in the pathogenesis of cancer. Immune regulatory cells are associated with the growth of cancer in the body. Antisenses for the key molecules can suppress tumor growth. This study tests the hypothesis that the antisense of survivin can inhibit cervical cancer.

RESULTS

The results showed that human cervical cancer cells expressed high levels of survivin. The levels of survivin in cervical cancer positively correlated with the frequency of interleukin (IL)-10-producing B cells (B10 cells) in the cancer tissue. Survivin increased the expression of IL-10 in B cells. Exposure to survivin antisense efficiently decreased IL-10 expression in B cells. Administration of antisense of survivin inhibited cervical cancer growth and reduced the frequency of B10 cells in tumor-bearing mice.

CONCLUSIONS

The results suggest that the survivin antisense has the potential to be used in the treatment of cervical cancer.

摘要

引言

有人提出生存素在癌症发病机制中起关键作用。免疫调节细胞与体内癌症的生长有关。针对关键分子的反义核酸可抑制肿瘤生长。本研究检验生存素反义核酸可抑制宫颈癌这一假说。

结果

结果显示，人宫颈癌细胞表达高水平的生存素。宫颈癌组织中生存素水平与产生白细胞介素（IL）-10的B细胞（B10细胞）频率呈正相关。生存素增加B细胞中IL-10的表达。暴露于生存素反义核酸可有效降低B细胞中IL-10的表达。给予生存素反义核酸可抑制荷瘤小鼠宫颈癌生长并降低B10细胞频率。

结论

结果表明生存素反义核酸有潜力用于宫颈癌治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/b21b717728c0/AMS-15-30893-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/560ad0972b4d/AMS-15-30893-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/fa2990caa63f/AMS-15-30893-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/e71129131096/AMS-15-30893-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/d09f4eef0609/AMS-15-30893-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/2eb70b59c3df/AMS-15-30893-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/b21b717728c0/AMS-15-30893-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/560ad0972b4d/AMS-15-30893-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/fa2990caa63f/AMS-15-30893-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/e71129131096/AMS-15-30893-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/d09f4eef0609/AMS-15-30893-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/2eb70b59c3df/AMS-15-30893-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41aa/6764320/b21b717728c0/AMS-15-30893-g006.jpg

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本文引用的文献

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Survivin: a unique target for tumor therapy.生存素：肿瘤治疗的独特靶点。
Cancer Cell Int. 2016 Jun 23;16:49. doi: 10.1186/s12935-016-0326-1. eCollection 2016.
2
Cervical cancer: screening, diagnosis and staging.宫颈癌：筛查、诊断与分期
J BUON. 2016 Mar-Apr;21(2):320-5.
3
Locally Advanced Cervical Cancer: Outcomes With Variable Adherence to Treatment.局部晚期宫颈癌：不同治疗依从性的结局
Am J Clin Oncol. 2018 May;41(5):447-451. doi: 10.1097/COC.0000000000000300.
4
Concurrent chemoradiotherapy for cervical cancer: background including evidence-based data, pitfalls of the data, limitation of treatment in certain groups.宫颈癌同步放化疗：背景，包括循证医学数据、数据缺陷以及特定人群治疗的局限性。
Chin J Cancer Res. 2016 Apr;28(2):221-7. doi: 10.21147/j.issn.1000-9604.2016.02.10.
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Advances in diagnosis and treatment of metastatic cervical cancer.转移性宫颈癌的诊断与治疗进展
J Gynecol Oncol. 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43.
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Current imaging strategies for the evaluation of uterine cervical cancer.评估子宫颈癌的当前成像策略。
World J Radiol. 2016 Apr 28;8(4):342-54. doi: 10.4329/wjr.v8.i4.342.
7
Transforming growth factor-β1 in carcinogenesis, progression, and therapy in cervical cancer.转化生长因子-β1在宫颈癌的致癌作用、进展及治疗中的作用
Tumour Biol. 2016 Jun;37(6):7075-83. doi: 10.1007/s13277-016-5028-8. Epub 2016 Mar 24.
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Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic Strategies.Survivin 与肿瘤发生：分子机制与治疗策略。
J Cancer. 2016 Jan 10;7(3):314-23. doi: 10.7150/jca.13332. eCollection 2016.
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Cervical Cancer Screening in Developing Countries: Using Visual Inspection Methods.发展中国家的宫颈癌筛查：采用视觉检查方法
Clin J Oncol Nurs. 2016 Feb;20(1):79-83. doi: 10.1188/16.CJON.79-83.
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Accuracy of Combined Visual Inspection with Acetic Acid and Cervical Cytology Testing as a Primary Screening Tool for Cervical Cancer: a Systematic Review and Meta-Analysis.联合醋酸目视检查与宫颈细胞学检测作为宫颈癌初筛工具的准确性：一项系统评价与荟萃分析
Asian Pac J Cancer Prev. 2015;16(14):5889-97. doi: 10.7314/apjcp.2015.16.14.5889.