生存素的反义核酸抑制小鼠宫颈癌生长。
Antisense of survivin inhibits cervical cancer growth in mice.
作者信息
Xu Hui, Liang Tingting, Yang Yongxia, Dong Yanlei, Zhu Lin
机构信息
Department of Gynecology, the Second Hospital, Shandong University, Jinan, China.
出版信息
Arch Med Sci. 2019 Sep;15(5):1345-1351. doi: 10.5114/aoms.2017.71069. Epub 2019 Sep 6.
INTRODUCTION
It is proposed that survivin plays a critical role in the pathogenesis of cancer. Immune regulatory cells are associated with the growth of cancer in the body. Antisenses for the key molecules can suppress tumor growth. This study tests the hypothesis that the antisense of survivin can inhibit cervical cancer.
RESULTS
The results showed that human cervical cancer cells expressed high levels of survivin. The levels of survivin in cervical cancer positively correlated with the frequency of interleukin (IL)-10-producing B cells (B10 cells) in the cancer tissue. Survivin increased the expression of IL-10 in B cells. Exposure to survivin antisense efficiently decreased IL-10 expression in B cells. Administration of antisense of survivin inhibited cervical cancer growth and reduced the frequency of B10 cells in tumor-bearing mice.
CONCLUSIONS
The results suggest that the survivin antisense has the potential to be used in the treatment of cervical cancer.
引言
有人提出生存素在癌症发病机制中起关键作用。免疫调节细胞与体内癌症的生长有关。针对关键分子的反义核酸可抑制肿瘤生长。本研究检验生存素反义核酸可抑制宫颈癌这一假说。
结果
结果显示，人宫颈癌细胞表达高水平的生存素。宫颈癌组织中生存素水平与产生白细胞介素（IL）-10的B细胞（B10细胞）频率呈正相关。生存素增加B细胞中IL-10的表达。暴露于生存素反义核酸可有效降低B细胞中IL-10的表达。给予生存素反义核酸可抑制荷瘤小鼠宫颈癌生长并降低B10细胞频率。
结论
结果表明生存素反义核酸有潜力用于宫颈癌治疗。
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