Crone-Escanye M C, Anghileri L J, Robert J
Tumori. 1985 Feb 28;71(1):39-43. doi: 10.1177/030089168507100107.
Hematoporphyrin derivative is currently used as a photochemotherapeutic agent in the treatment of neoplasms. The uptake of hematoporphyrin derivative was determined in vitro and as a function of time with Ehrlich ascites cells in the presence of lanthanum and in vivo with VFM1, tumor-bearing mice pretreated by intratumoral injection of LaCl3. Our results indicate that the treatment with lanthanum increases the uptake of hematoporphyrin derivative by tumor cells.
血卟啉衍生物目前作为一种光化学治疗剂用于肿瘤治疗。在镧存在的情况下，体外测定了血卟啉衍生物在艾氏腹水癌细胞中的摄取及其随时间的变化情况；在体内，对预先经瘤内注射LaCl3处理的荷瘤小鼠VFM1进行了测定。我们的结果表明，镧处理可增加肿瘤细胞对血卟啉衍生物的摄取。
