Mahrle G, Bauermeister-Jasso K, Enderer K
Z Hautkr. 1985 Jan;60(1-2):120, 125-34.
Isotretinoin (Accutane) is a lately developed synthetic oral retinoid for treatment of severe forms of cystic acne resistant to therapy. Its pharmacological effect principally consists in decreased size of the sebaceous glands, reduced sebum production, as well as alteration of the bacterial micropopulation. At a dosage of 0.5 mg up to 1.0 mg/kg body weight daily, isotretinoin led to significant reduction of the inflammatory skin eruptions and long-lasting remission after discontinuation of the drug. With regard to 18 patients suffering from rosacea, the application of Accutane brought about satisfactory results, as well. Mucocutaneous side-effects were almost compulsory, but did never lead to discontinuation of the treatment. Because of its teratogenity, isotretinoin must not be applied in case of gravidity. Accutane offers new modes of therapy with respect to patients suffering from nodulocystic acne or severe rosacea which did not respond to common forms of treatment.
异维甲酸（泰尔丝）是一种最新研制的合成口服类维生素A，用于治疗对治疗有抵抗性的重度囊肿性痤疮。其药理作用主要包括皮脂腺大小减小、皮脂分泌减少以及细菌微群落的改变。每日剂量为0.5毫克至1.0毫克/千克体重时，异维甲酸可显著减少炎性皮肤疹，停药后可实现长期缓解。对于18名酒渣鼻患者，使用泰尔丝也取得了满意的效果。皮肤黏膜副作用几乎是必然的，但从未导致治疗中断。由于其致畸性，怀孕时不得使用异维甲酸。对于结节囊肿性痤疮或重度酒渣鼻且对常规治疗无反应的患者，泰尔丝提供了新的治疗方式。
