Genvert G I, Cohen E J, Donnenfeld E D, Blecher M H
Am J Ophthalmol. 1985 Apr 15;99(4):465-8. doi: 10.1016/0002-9394(85)90014-5.
An 8-year-old boy developed erythema multiforme major after topical administration of sodium sulfacetamide for conjunctivitis. He had received systemic treatment with trimethoprim-sulfamethoxazole four months previously without evidence of drug allergy. There was no history of recent exposure to other drugs or evidence of herpes simplex or Mycoplasma infection. After 12 days of treatment with erythromycin ointment, 1% prednisolone eyedrops, systemic prednisone, and intravenous nafcillin, the patient's condition improved dramatically. A slit-lamp examination showed only superficial punctate keratitis. Two months later his visual acuity had improved from 20/200 bilaterally to R.E.: 20/40 and L.E.: 20/30.
一名8岁男孩因局部使用磺胺醋酰钠治疗结膜炎后发生重症多形红斑。他在四个月前接受过甲氧苄啶-磺胺甲恶唑全身治疗，当时无药物过敏迹象。近期无接触其他药物史，也无单纯疱疹或支原体感染证据。在用红霉素眼膏、1%泼尼松龙滴眼液、全身用泼尼松及静脉注射萘夫西林治疗12天后，患者病情显著改善。裂隙灯检查仅显示浅表点状角膜炎。两个月后，他的视力从双侧20/200提高到右眼：20/40，左眼：20/30。
