Mackay Base Hospital, Mackay, QLD 4740, Australia.
Australas J Dermatol. 2013 May;54(2):144-6. doi: 10.1111/j.1440-0960.2012.00936.x. Epub 2012 Aug 17.
We present a case of a 15-year-old boy who developed toxic epidermal necrolysis (TEN) from sulfacetamide eyedrops. He presented with conjunctival injection and an erythematous rash that rapidly progressed to epidermal necrosis of over 30% of his body. A skin biopsy revealed an acute lichenoid reaction pattern consistent with TEN. After 22 days in hospital, he was left with significant scarring to his eyes, mouth and anogenital areas. An extensive search for an infective aetiology was negative. Previously exposed to bactrim tablets, he used Bleph-10 eyedrops 3 days before admission to hospital. The patient had a strong family history of sulphur allergy. The onset of TEN after topical administration of medication has been reported rarely in the literature. This case highlights the need for a thorough medication history that includes topical preparations.
我们报告了一例 15 岁男孩因使用磺胺醋酰钠滴眼剂而发生中毒性表皮坏死松解症（TEN）的病例。他最初表现为结膜充血和红斑，迅速发展为超过 30%的皮肤表皮坏死。皮肤活检显示一种急性苔藓样反应模式，符合 TEN 的表现。住院 22 天后，他的眼睛、口腔和肛门生殖器区域留下了明显的疤痕。对感染病因进行了广泛的搜索，但结果均为阴性。该患者曾接触过复方磺胺甲噁唑片，在入院前 3 天使用了 Bleph-10 滴眼剂。他有强烈的家族性硫磺过敏史。该病例强调了需要进行全面的用药史询问，包括局部制剂。
