Centre for Nanotechnology Research, Vellore Institute of Technology, Vellore-632014, TN, India.
School of Bioscience and Technology, Vellore Institute of Technology, Vellore-632014, TN, India.
IET Nanobiotechnol. 2019 Sep;13(7):682-687. doi: 10.1049/iet-nbt.2018.5330.
Antibacterial activity of nanoparticles (NPs) and nanocomposites (NCs) has received wide spread attention in biomedical applications. In this direction, the authors prepared zinc oxide (ZnO), iron oxide (FeO), and their composite including reduced graphene oxide (rGO) by hydrothermal method. The structural and microstructural properties of the synthesised NPs and NCs were investigated by XRD, FT-IR, UV-Vis, TGA, and TEM analysis. PEG-coated ZnO and FeO form in hexagonal wurtzite and inverse spinel structures, respectively. ZnO forms in rod-shaped (aspect ratio of ∼3) morphology, whereas well-dispersed spherical-shaped morphology of ∼10 nm is observed in FeO NPs. The ZnO/FeO composite possesses a homogeneous distribution of above two phases and shows a very good colloidal stability in aqueous solvent. These synthesised particles exhibited varying antibacterial activity against gram-positive strain Staphylococcus aureus (S. aureus) and gram-negative strain Escherichia coli (E. coli). The nanocomposite exhibits a better cidal effect on E. coli when compared to S. aureus when treated with 1 mg/ml concentration. Further, the addition of rGO has intensified the anti-bacterial effect to a much higher extent due to synergistic influence of individual components.
纳米粒子（NPs）和纳米复合材料（NCs）的抗菌活性在生物医学应用中受到了广泛关注。在这个方向上，作者通过水热法制备了氧化锌（ZnO）、氧化铁（FeO）及其包括还原氧化石墨烯（rGO）的复合材料。通过 XRD、FT-IR、UV-Vis、TGA 和 TEM 分析研究了合成的 NPs 和 NCs 的结构和微观结构特性。PEG 包覆的 ZnO 和 FeO 分别形成六方纤锌矿和反尖晶石结构。ZnO 呈棒状（纵横比约为 3）形态，而在 FeO NPs 中观察到分散良好的 10nm 左右的球形形态。ZnO/FeO 复合材料具有上述两种相的均匀分布，并在水溶剂中表现出非常好的胶体稳定性。这些合成的颗粒表现出对革兰氏阳性菌株金黄色葡萄球菌（S. aureus）和革兰氏阴性菌株大肠杆菌（E. coli）的不同抗菌活性。与 S. aureus 相比，当用 1mg/ml 浓度处理时，纳米复合材料对 E. coli 表现出更好的杀菌效果。此外，由于各组分的协同影响，添加 rGO 使抗菌效果大大增强。
