Li Honghai, Chen Yu, Lu Weipeng, Xu Yisheng, Guo Yanchuan, Yang Geng
Key Laboratory of Photochemical Conversion and Optoelectronic Material, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.
Molecules. 2020 Feb 26;25(5):1043. doi: 10.3390/molecules25051043.
Current wound dressings have poor antimicrobial activities and are difficult to degrade. Therefore, biodegradable and antibacterial dressings are urgently needed. In this article, we used the hydrothermal method and side-by-side electrospinning technology to prepare a gelatin mat with incorporated zinc oxide/graphene oxide (ZnO/GO) nanocomposites. The resultant fibers were characterized by field emission environment scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FTIR). Results indicated that the gelatin fibers had good morphology, and ZnO/GO nanocomposites were uniformly dispersed on the fibers. The loss of () and () viability were observed to more than 90% with the incorporation of ZnO/GO. The degradation process showed that the composite fibers completely degraded within 7 days and had good controllable degradation characteristics. This study demonstrated the potential applicability of ZnO/GO-gelatin mats with excellent antibacterial properties as wound dressing material.
目前的伤口敷料抗菌活性较差且难以降解。因此，迫切需要可生物降解且具有抗菌性能的敷料。在本文中，我们采用水热法和并列静电纺丝技术制备了一种含有氧化锌/氧化石墨烯（ZnO/GO）纳米复合材料的明胶垫。通过场发射环境扫描电子显微镜（FESEM）、能量色散X射线光谱仪（EDX）、X射线衍射仪（XRD）和傅里叶变换红外光谱仪（FTIR）对所得纤维进行了表征。结果表明，明胶纤维形态良好，ZnO/GO纳米复合材料均匀分散在纤维上。加入ZnO/GO后，观察到（）和（）的活力损失超过90%。降解过程表明，复合纤维在7天内完全降解，具有良好的可控降解特性。本研究证明了具有优异抗菌性能的ZnO/GO-明胶垫作为伤口敷料材料的潜在适用性。
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