Ball M D, Furr H C, Olson J A
Biochem Biophys Res Commun. 1985 Apr 16;128(1):7-11. doi: 10.1016/0006-291x(85)91636-5.
Retinol esterification by microsomal acyl coenzyme A:retinol acyltransferase was quantified in rat mammary tumor and liver tissue. Acyltransferase activity in the livers of mammary tumor-bearing rats was 40% of that in normal animals. In response to daily oral doses of 2 mg retinyl acetate for 18-19 days, activity increased 2.8-fold in transplanted rat mammary tumors, 4.1-fold in the livers of tumor-bearing rats, and 1.5-fold in the livers of normal rats. The in vitro esterification of retinol was competitively inhibited by all-trans-N-(4-hydroxyphenyl) retinamide (Ki = 154 microM).
通过微粒体酰基辅酶A：视黄醇酰基转移酶进行的视黄醇酯化在大鼠乳腺肿瘤和肝脏组织中进行了定量分析。患乳腺肿瘤大鼠肝脏中的酰基转移酶活性是正常动物的40%。在每天口服2毫克醋酸视黄酯，持续18 - 19天的情况下，移植的大鼠乳腺肿瘤中的活性增加了2.8倍，患肿瘤大鼠肝脏中的活性增加了4.1倍，正常大鼠肝脏中的活性增加了1.5倍。视黄醇的体外酯化受到全反式-N-(4-羟基苯基)视黄酰胺的竞争性抑制（Ki = 154微摩尔）。
