人肝脏中视黄醇的微粒体酯化作用。
Microsomal esterification of retinol in human liver.
作者信息
Rasmussen M, Helgerud P, Petersen L B, Norum K R
出版信息
Acta Med Scand. 1984;216(4):403-7. doi: 10.1111/j.0954-6820.1984.tb03824.x.
Recent work has shown that esterification of retinol in microsomes from rat liver, mammary gland and small intestine and from human small intestine is catalyzed by an acyl CoA: retinol acyl transferase (ARAT). The current study demonstrates ARAT activity in human liver microsomes. At optimal incubation conditions the rate of retinyl ester formation due to ARAT (0.37 +/- 0.31 nmole ester formed X mg microsomal protein-1 X minute-1, mean +/- SD, n = 6) suggests that the enzyme is of physiological importance.
近期研究表明，大鼠肝脏、乳腺、小肠以及人类小肠微粒体中的视黄醇酯化作用是由酰基辅酶A：视黄醇酰基转移酶（ARAT）催化的。本研究证实了人类肝脏微粒体中存在ARAT活性。在最佳孵育条件下，由ARAT介导的视黄酯形成速率（0.37±0.31纳摩尔酯形成×毫克微粒体蛋白⁻¹×分钟⁻¹，平均值±标准差，n = 6）表明该酶具有重要的生理意义。
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