替诺昔康对格列本脲动力学及反应无影响。
Lack of effect of tenoxicam on glibornuride kinetics and response.
作者信息
Stoeckel K, Trueb V, Dubach U C, Heintz R C, Ascalone V, Forgo I, Hennes U
出版信息
Br J Clin Pharmacol. 1985 Feb;19(2):249-54. doi: 10.1111/j.1365-2125.1985.tb02638.x.
Abstract
The pharmacokinetics of glibornuride (25 mg i.v.) and the accompanying insulin and glucose responses were characterized in eight human subjects in the presence and absence of steady-state tenoxicam (20 mg p.o./day for 2 weeks). Tenoxicam affected neither the pharmacokinetic parameters of glibornuride (systemic clearance, volume of distribution and biological half-life) nor the responses of plasma insulin and blood glucose to glibornuride. The single i.v. dose of glibornuride had no detectable effect on the kinetics of tenoxicam.
摘要
在8名人类受试者中，研究了在存在和不存在稳态替诺昔康（每天口服20mg，持续2周）的情况下，格列本脲（静脉注射25mg）的药代动力学以及伴随的胰岛素和葡萄糖反应。替诺昔康既不影响格列本脲的药代动力学参数（全身清除率、分布容积和生物半衰期），也不影响血浆胰岛素和血糖对格列本脲的反应。单次静脉注射格列本脲对替诺昔康的动力学没有可检测到的影响。
相似文献
1
Lack of effect of tenoxicam on glibornuride kinetics and response.替诺昔康对格列本脲动力学及反应无影响。
Br J Clin Pharmacol. 1985 Feb;19(2):249-54. doi: 10.1111/j.1365-2125.1985.tb02638.x.
2
A pharmacokinetic comparison of tenoxicam in plasma and synovial fluid.吡罗昔康在血浆和滑液中的药代动力学比较。
Br J Rheumatol. 1985 Nov;24(4):351-6. doi: 10.1093/rheumatology/24.4.351.
3
Metabolism of tenoxicam in rats.
Xenobiotica. 1984 Sep;14(9):727-39. doi: 10.3109/00498258409151471.
4
Pharmacokinetics of tenoxicam in patients with impaired renal function.
Eur J Clin Pharmacol. 1986;29(6):697-701. doi: 10.1007/BF00615961.
5
[Biliary excretion of tenoxicam in cholecystectomized patients].
Nihon Geka Hokan. 1984 Nov 1;53(6):779-85.
6
Single-dose and steady-state pharmacokinetics of piroxicam in elderly vs young adults.吡罗昔康在老年人与年轻人中的单剂量及稳态药代动力学
Eur J Clin Pharmacol. 1985;28(3):305-9. doi: 10.1007/BF00543328.
7
Effect of impairment of renal function on the accumulation and disposition of isoxicam.肾功能损害对异恶酰胺蓄积和处置的影响。
Eur J Clin Pharmacol. 1985;28(5):585-8. doi: 10.1007/BF00544071.
8
[On the multiple-dose kinetics of glibornuride in man (author's transl)].关于格列本脲在人体中的多剂量动力学（作者译）
Arzneimittelforschung. 1975;25(12):1967-9.
9
Pharmacokinetic observations on piroxicam in young adult, middle-aged and elderly patients.吡罗昔康在青年、中年和老年患者中的药代动力学观察。
Br J Clin Pharmacol. 1983 Oct;16(4):433-7. doi: 10.1111/j.1365-2125.1983.tb02191.x.
10
Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide.替诺昔康对同时口服葡萄糖和格列本脲的动态反应无影响。
Br J Clin Pharmacol. 1990 Aug;30(2):245-52. doi: 10.1111/j.1365-2125.1990.tb03771.x.
引用本文的文献
1
Adverse drug interactions with nonsteroidal anti-inflammatory drugs (NSAIDs). Recognition, management and avoidance.非甾体抗炎药（NSAIDs）的药物不良相互作用。识别、管理与避免。
Drug Saf. 1993 Feb;8(2):99-127. doi: 10.2165/00002018-199308020-00002.
2
Clinical pharmacokinetics of tenoxicam.替诺昔康的临床药代动力学
Clin Pharmacokinet. 1994 Jan;26(1):16-43. doi: 10.2165/00003088-199426010-00003.
3
Tenoxicam. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.替诺昔康。对其药效学、药代动力学特性及治疗效果的初步综述。
Drugs. 1987 Sep;34(3):289-310. doi: 10.2165/00003495-198734030-00001.
4
Pharmacokinetic drug interactions with nonsteroidal anti-inflammatory drugs.非甾体抗炎药的药代动力学药物相互作用。
Clin Pharmacokinet. 1990 Jul;19(1):44-66. doi: 10.2165/00003088-199019010-00004.
5
Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide.替诺昔康对同时口服葡萄糖和格列本脲的动态反应无影响。
Br J Clin Pharmacol. 1990 Aug;30(2):245-52. doi: 10.1111/j.1365-2125.1990.tb03771.x.
本文引用的文献
1
[Glucose determination in the hemolysate, manual analysis].[溶血产物中葡萄糖的测定，手工分析]
Schweiz Med Wochenschr. 1980 Mar 29;110(13):491-5.
2
Determination of Ro12-0068, a new anti-inflammatory and analgesic compound, in plasma by means of high-performance liquid chromatography.
J Chromatogr. 1981 Oct 9;225(2):493-7. doi: 10.1016/s0378-4347(00)80302-3.
3
[Pharmacologic studies on Ro 12-0068, a new non-steroidal anti-inflammatory drug (author's transl)].
Nihon Yakurigaku Zasshi. 1981 May;77(5):531-52.
4
Concepts basic to pharmacokinetics.药物动力学的基本概念。
Pharmacol Ther. 1981;12(1):109-31. doi: 10.1016/0163-7258(81)90077-2.
5
Effect of pirprofen on glibenclamide kinetics and response.吡洛芬对格列本脲动力学及反应的影响。
Br J Clin Pharmacol. 1982 Jul;14(1):123-6. doi: 10.1111/j.1365-2125.1982.tb04949.x.
6
Clinical pharmacokinetics of non-steroidal anti-inflammatory drugs.非甾体抗炎药的临床药代动力学
Clin Pharmacokinet. 1983 Jul-Aug;8(4):297-331. doi: 10.2165/00003088-198308040-00003.
7
[Pharmacokinetics of glibornuride].
Arzneimittelforschung. 1972 Dec;22:Suppl 12A:2209.
8
[Micromethod for the determination of glucose with glucose dehydrogenase in the autoanalyzer (author's transl)].自动分析仪中用葡萄糖脱氢酶测定葡萄糖的微量法（作者译）
J Clin Chem Clin Biochem. 1976 Apr;14(4):189-95.
9
Noncompartmental determination of the steady-state volume of distribution.稳态分布容积的非房室测定
J Pharm Sci. 1979 Aug;68(8):1071-4. doi: 10.1002/jps.2600680845.
10
Drug interactions with oral sulphonylurea hypoglycaemic drugs.口服磺酰脲类降糖药的药物相互作用。
Drugs. 1977 Jan;13(1):24-34. doi: 10.2165/00003495-197713010-00003.
Zotero 插件