吡洛芬对格列本脲动力学及反应的影响。
Effect of pirprofen on glibenclamide kinetics and response.
作者信息
Morrison P J, Rogers H J, Spector R G, Bradbrook I D, John V A
出版信息
Br J Clin Pharmacol. 1982 Jul;14(1):123-6. doi: 10.1111/j.1365-2125.1982.tb04949.x.
Abstract
Pirprofen (a new non-steroidal anti-inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose and insulin responses after 1 mg i.v. glibenclamide. No significant changes were produced in these measures and in vitro studies showed no displacement of glibenclamide by pirprofen from plasma protein binding.
摘要
将吡洛芬（一种新型非甾体抗炎药）以每8小时200毫克的剂量口服给予8名正常志愿者，或给予安慰剂，以研究其对静脉注射1毫克格列本脲后的药代动力学以及葡萄糖和胰岛素反应的影响。这些指标未产生显著变化，体外研究表明吡洛芬不会从血浆蛋白结合中置换格列本脲。
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本文引用的文献
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Effect of naproxen on glucose metabolism and tolbutamide kinetics and dynamics in maturity onset diabetics.萘普生对成年型糖尿病患者葡萄糖代谢及甲苯磺丁脲动力学和动态变化的影响。
Br J Clin Pharmacol. 1981 Mar;11(3):295-302. doi: 10.1111/j.1365-2125.1981.tb00537.x.
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Comparative single-dose kinetics and effects of four sulfonylureas in healthy volunteers.四种磺酰脲类药物在健康志愿者中的单剂量比较动力学及效应
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Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen.使用带有非致癌显色剂的氧化酶-过氧化物酶系统测定血糖。
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[Studies on the bioavailability of glibenclamide].[格列本脲生物利用度的研究]
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Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole.甲苯磺丁脲代谢抑制机制：保泰松、羟基保泰松、磺胺苯吡唑。
Clin Pharmacol Ther. 1977 Nov;22(5 Pt 1):573-9. doi: 10.1002/cpt1977225part1573.
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ESTRIP, a BASIC computer program for obtaining initial polyexponential parameter estimates.ESTRIP，一个用于获取初始多指数参数估计值的BASIC计算机程序。
J Pharm Sci. 1978 Dec;67(12):1687-91. doi: 10.1002/jps.2600671214.
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Diabetes. 1978 Dec;27(12):1196-1204. doi: 10.2337/diab.27.12.1196.
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