吡洛芬对格列本脲动力学及反应的影响。
Effect of pirprofen on glibenclamide kinetics and response.
作者信息
Morrison P J, Rogers H J, Spector R G, Bradbrook I D, John V A
出版信息
Br J Clin Pharmacol. 1982 Jul;14(1):123-6. doi: 10.1111/j.1365-2125.1982.tb04949.x.
Abstract
Pirprofen (a new non-steroidal anti-inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose and insulin responses after 1 mg i.v. glibenclamide. No significant changes were produced in these measures and in vitro studies showed no displacement of glibenclamide by pirprofen from plasma protein binding.
摘要
将吡洛芬（一种新型非甾体抗炎药）以每8小时200毫克的剂量口服给予8名正常志愿者，或给予安慰剂，以研究其对静脉注射1毫克格列本脲后的药代动力学以及葡萄糖和胰岛素反应的影响。这些指标未产生显著变化，体外研究表明吡洛芬不会从血浆蛋白结合中置换格列本脲。
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