[生理激活剂和真菌源酶作用诱导动物纤维蛋白溶解系统成分的变化]

[Changes in the components of the animal fibrinolytic system induced by the action of physiological activators and enzymes of fungal origin].

作者信息

Andreenko G V, Serebriakova T N, Shimonaeva E E, Liutova L V, Karabasova M A

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1983(3):51-4.

Abstract

The rat fibrinolytic system components by means of intravenous injection of physiological activators (tissue plasminogen activator, urokinase) and of enzymes isolated from the Fungi imeprfecti cultures (tricholysin, longolytin) have been investigated. It has been demonstrated that the tissue plasminogen activator and urokinase exert a similar effect on fibrinolysis by inducing a short-term increase of the euglobulin fraction fibrinolytic activity but do not practically change other components of the fibrinolytic system including the antiplasmin content. Tricholysin and longolytin produce a stronger action on the fibrinolytic system by significant affecting almost all the parameters, especially the antiplasmin content. The results obtained show that physiological activators as compared with fungal enzymes possess with better thrombolytic properties.

摘要

通过静脉注射生理激活剂（组织纤溶酶原激活剂、尿激酶）以及从不完全真菌培养物中分离出的酶（曲古溶素、长溶素），对大鼠纤维蛋白溶解系统的成分进行了研究。结果表明，组织纤溶酶原激活剂和尿激酶对纤维蛋白溶解具有相似的作用，它们可诱导优球蛋白部分纤维蛋白溶解活性短期增加，但实际上不会改变纤维蛋白溶解系统的其他成分，包括抗纤溶酶含量。曲古溶素和长溶素对纤维蛋白溶解系统的作用更强，它们几乎会显著影响所有参数，尤其是抗纤溶酶含量。所得结果表明，与真菌酶相比，生理激活剂具有更好的溶栓特性。