Facultad de Ciencias Naturales e IML, Universidad Nacional de Tucumán, Argentina; Instituto de Bioprospección y Fisiología Vegetal (INBIOFIV), CONICET-UNT, San Miguel de Tucumán, Tucumán, Argentina.
J Ethnopharmacol. 2020 Jan 30;247:112258. doi: 10.1016/j.jep.2019.112258. Epub 2019 Sep 28.
In northwestern Argentina inhabit several ancient indigenous communities with diverse cultural and historical background. Geographical isolation has contributed to the prevalence of a native plant-based folk medicine; "jarilla" species are medicinal plants widely used in local communities for the treatment of mycosis, respiratory, gastrointestinal and rheumatic disorders.
To assemble the traditional knowledge acquired through years with scientific data concerning to phytochemistry, antioxidant and anti-inflammatory potential of three "jarillas" species.
Ethnobotanical data of three "jarillas", Zuccagnia punctata (Zp), Larrea cuneifolia (Lc), and Larrea divaricata (Ld), were explored by interviewing native people from Indigenous Community of Amaicha del Valle, Tucumán. Phenolic profiles from each infusion were analyzed by HPLC-ESI-MS/MS. Antioxidant activity was determined by superoxide anion and hydrogen peroxide scavenging capacity, lipoperoxidation inhibition, and ferrous iron chelating activity. It was also assessed their ability to inhibit pro-inflammatory enzymes, such as xanthine oxidase, lipoxygenase, and hyaluronidase.
Ethnobotanical interviews showed that local people use "jarillas" mainly as infusions and baths. It was reported different categories of uses, such as medicinal (10 curative applications), to religious purposes, tinctorial, as construction material and as fuel. From infusions prepared, the MS and MS/MS data allowed the identification of 27 compounds from Z. punctata, and 11 from both Larrea sp. The infusions showed an important antioxidant activity through different mechanisms, highlighting Zp and Lc in free radical scavenging capacity and Ld on lipid peroxidation inhibition and iron binding. They were also capable of inhibit xanthine oxidase and lipoxygenase enzymes, being Lc the most active one.
This research work provides novel information concerning to several categories of traditional uses of "jarilla" species in a Diaguita-Calchaquí community and focus attention to infusions from a phytochemical and biological approach.
在阿根廷西北部，有几个古老的土著社区，拥有不同的文化和历史背景。地理隔离促成了以当地植物为基础的民间医学的流行；“jarilla”物种是药用植物，在当地社区广泛用于治疗真菌感染、呼吸道、胃肠道和风湿疾病。
收集多年来通过访谈从土著社区获得的传统知识，并结合有关三种“jarilla”物种的植物化学、抗氧化和抗炎潜力的科学数据。
通过访谈来自图库曼 Amaicha del Valle 土著社区的当地人，探讨了三种“jarilla”物种，即 Zuccagnia punctata（Zp）、Larrea cuneifolia（Lc）和 Larrea divaricata（Ld）的民族植物学数据。通过 HPLC-ESI-MS/MS 分析每种浸液的酚类图谱。通过超氧阴离子和过氧化氢清除能力、脂质过氧化抑制和亚铁螯合活性来测定抗氧化活性。还评估了它们抑制黄嘌呤氧化酶、脂氧合酶和透明质酸酶等促炎酶的能力。
民族植物学访谈显示，当地人主要将“jarillas”用作浸液和浴液。报告了不同的用途类别，如药用（10 种治疗应用）、宗教用途、染色、建筑材料和燃料。从制备的浸液中，MS 和 MS/MS 数据允许鉴定出 Z. punctata 中的 27 种化合物，以及 Larrea sp. 中的 11 种化合物。浸液通过不同的机制表现出重要的抗氧化活性，突出了 Zp 和 Lc 在自由基清除能力方面，以及 Ld 在脂质过氧化抑制和铁结合方面的作用。它们还能够抑制黄嘌呤氧化酶和脂氧合酶酶，其中 Lc 最为活跃。
这项研究工作提供了有关 Diaguita-Calchaquí 社区中几种“jarilla”物种传统用途的新信息，并从植物化学和生物学角度关注浸液。
