Department of Surgery and Translational Medicine, Division of Dermatology.
Cancer Research 'Attilia Pofferi' Foundation, Pistoia.
Melanoma Res. 2020 Apr;30(2):179-184. doi: 10.1097/CMR.0000000000000579.
A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The aim of this study was to investigate a possible relationship between the number of common and atypical nevi and melanoma prognostic factors. We carried out a retrospective analysis of patients with a histopathologically confirmed diagnosis of melanoma. These patients were treated at the Dermatology Clinic of the University of Florence from January 2000 to December 2013. The main analysis investigated the association of common and atypical nevi with Breslow thickness and ulceration. The number of nevi was investigated as a continuous variable and a categorical variable considering the median number of common nevi, given the skewness of the distribution of common nevi. We analyzed 818 melanoma patients treated from January 2000 to December 2013. We found a sex and nevi interaction: among women, thick melanomas occur more frequently in patients with a low common nevi count (<10); no association was found in men. This sex and nevi interaction was also found considering the association with very thick melanomas (Breslow > 4 mm). Moreover, the presence of an increasing number of atypical nevi was associated with increased risk of ulceration in both sexes. These data provide new perspectives in the differential sex-related biological behavior of melanoma among females and males.
大量科学文献中的证据表明，普通痣和非典型痣的数量是皮肤恶性黑色素瘤发生的强有力的独立危险因素。此外，一些研究最近发现痣数量与黑色素瘤预后改善之间存在关联。本研究旨在探讨普通痣和非典型痣的数量与黑色素瘤预后因素之间可能存在的关系。我们对 2000 年 1 月至 2013 年 12 月在佛罗伦萨大学皮肤科诊所接受治疗的组织学证实为黑色素瘤的患者进行了回顾性分析。主要分析研究了普通痣和非典型痣与 Breslow 厚度和溃疡之间的关联。考虑到普通痣分布的偏态性，将痣的数量作为连续变量和分类变量进行了研究，考虑了普通痣的中位数数量。我们分析了 818 名 2000 年 1 月至 2013 年 12 月期间接受治疗的黑色素瘤患者。我们发现了性别和痣之间的相互作用：在女性中，薄黑色素瘤在普通痣计数低（<10）的患者中更常见；在男性中则没有发现关联。这种性别和痣之间的相互作用也存在于与非常厚的黑色素瘤（Breslow > 4 毫米）的关联中。此外，非典型痣数量的增加与两性溃疡风险的增加相关。这些数据为女性和男性中黑色素瘤的性别相关生物学行为的差异提供了新的视角。
