Jiang Chao, Wang Ting, Ma Zhen, Fang Bang-Jiang
The Third Department of Neurology, The Second Affiliated Hospital of Xi'an Medical University.
Department of Emergency, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai.
Medicine (Baltimore). 2019 Sep;98(39):e17273. doi: 10.1097/MD.0000000000017273.
Previous study has reported that Fuyuan Xingnao Decoction (FYXND) can be utilized for the treatment of patients with diabetes mellitus (DM) combined cerebral infarction (CI) effectively.
We will search from the following databases of MEDLINE, EMBASE, Cochrane Library, PsycINFO, Global Health, Web of Science, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All databases will be searched from the inception to the present without language limitation. Two independent authors will perform literature selection, information collection, and methodological quality assessment. Statistical analysis will be carried out using RevMan 5.3 software.
This study will provide accurate results on the effectiveness and safety of FYXND on DM and CI through primary and secondary outcomes. The primary outcome is neurological deficit. The secondary outcomes consist of fasting blood glucose, hemoglobin Alc, fasting insulin, quality of life, and adverse effects.
This well-designed study will establish high quality evidence of the effectiveness and safety of FYXND for DM and CI to facilitate the clinical practice and guideline development.
先前的研究报道，复元醒脑汤（FYXND）可有效用于治疗糖尿病（DM）合并脑梗死（CI）患者。
我们将检索以下数据库：MEDLINE、EMBASE、Cochrane图书馆、PsycINFO、全球卫生、科学引文索引、补充与替代医学数据库、中国生物医学文献数据库和中国知网。所有数据库将从创建至今进行检索，无语言限制。两名独立作者将进行文献筛选、信息收集和方法学质量评估。将使用RevMan 5.3软件进行统计分析。
本研究将通过主要和次要结局提供关于复元醒脑汤对糖尿病和脑梗死有效性和安全性的准确结果。主要结局是神经功能缺损。次要结局包括空腹血糖、糖化血红蛋白、空腹胰岛素、生活质量和不良反应。
这项精心设计的研究将建立复元醒脑汤治疗糖尿病和脑梗死有效性和安全性的高质量证据，以促进临床实践和指南制定。
