Zhang You-Jie, Liu Fan-Rong
Department of Integrated Chinese and Western Medicine, Shangluo Central Hospital.
Department of Gastroenterology, Shangluo Central Hospital, Shangluo, China.
Medicine (Baltimore). 2019 Sep;98(39):e17282. doi: 10.1097/MD.0000000000017282.
This study will assess the effectiveness and safety of acupuncture for the treatment of patients with diabetic peripheral neuropathy (DPN).
We will comprehensively search electronic databases of MEDLINE, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, and China National Knowledge Infrastructure from their inception to July 1, 2019. We will also search grey literature to avoid missing any potential studies. Randomized controlled trials related to acupuncture for the treatment of DPN will be included. All record literatures are searched without language limitation. Two researchers will independently carry out research selection, data extraction, and research quality evaluation. We will perform RevMan 5.3 software for statistical analysis.
Primary outcomes consist of severity of neuropathy and pain intensity. Secondary outcomes include diabetes mellitus duration, body mass index, HbA1c level, blood glucose levels, and adverse events.
The findings of this study will summarize recent evidence for the effectiveness and safety of acupuncture for the treatment of patients with DPN.
We will not analyze individual data, thus no ethic approval is needed. The results of this study are expected to be published at a peer-reviewed journal.
PROSPERO CRD42019139635.
本研究将评估针刺治疗糖尿病周围神经病变（DPN）患者的有效性和安全性。
我们将全面检索MEDLINE、EMBASE、Cochrane图书馆、科学网、中国生物医学文献数据库、中国科学期刊数据库和中国知网等电子数据库，检索时间从各数据库建库至2019年7月1日。我们还将检索灰色文献，以避免遗漏任何潜在的研究。纳入与针刺治疗DPN相关的随机对照试验。所有检索记录的文献均无语言限制。两名研究人员将独立进行研究筛选、数据提取和研究质量评估。我们将使用RevMan 5.3软件进行统计分析。
主要结局包括神经病变严重程度和疼痛强度。次要结局包括糖尿病病程、体重指数、糖化血红蛋白水平、血糖水平和不良事件。
本研究结果将总结近期针刺治疗DPN患者有效性和安全性的证据。
我们不会分析个体数据，因此无需伦理批准。本研究结果预计将发表在同行评审期刊上。
PROSPERO注册号：PROSPERO CRD42019139635。
