Yildirim Erkan, Ermis Emrah, Allahverdiyev Samir, Ucar Hakan, Yavuzer Serap, Cengiz Mahir
Department of Cardiology.
Department of Internal Medicine, Biruni University Faculty of Medicine, İstanbul, Turkey.
Medicine (Baltimore). 2019 Sep;98(39):e17297. doi: 10.1097/MD.0000000000017297.
As a modifiable risk factor for cardiovascular disease, presence of hypertension (HT) necessitates the awareness of asymptomatic organ damage (AOD). The aim of this study was to measure plasma micro RNA-21 (miR-21) and the parameters that reflect AOD such as carotid intima-media thickness (CIMT), microalbuminuria (MAU) in hypertensive patients compared with healthy controls. In addition, the aim of this study was to evaluate plasma miR-21 levels in HT patients with AOD.This study was designed as a cross-sectional observational study. The study includes 2 groups: 32 patients with HT and 32 healthy controls. First, we compared these 2 groups. Then, to underline the relationship between plasma miR-21 and HT, hypertensive patients were divided into 2 groups: with AOD and without AOD.Sixteen patients with HT had AOD. MiR-21 levels significantly correlated with clinical systolic and diastolic blood pressure, MAU, C-reactive protein, and CIMT. CIMT, miR-21, and MAU levels were significantly higher in patients with AOD.Our study showed increased miR-21 levels in HT patients with AOD.
作为心血管疾病的一个可改变风险因素，高血压（HT）的存在需要意识到无症状器官损伤（AOD）。本研究的目的是测量高血压患者与健康对照者的血浆微小RNA-21（miR-21）以及反映AOD的参数，如颈动脉内膜中层厚度（CIMT）、微量白蛋白尿（MAU）。此外，本研究的目的是评估有AOD的HT患者的血浆miR-21水平。本研究设计为横断面观察性研究。该研究包括2组：32例HT患者和32例健康对照者。首先，我们比较了这2组。然后，为了强调血浆miR-21与HT之间的关系，将高血压患者分为2组：有AOD组和无AOD组。16例HT患者有AOD。MiR-21水平与临床收缩压和舒张压、MAU、C反应蛋白及CIMT显著相关。有AOD患者的CIMT、miR-21和MAU水平显著更高。我们的研究表明有AOD的HT患者的miR-21水平升高。
