Medeiros Amanda Fernandes de, Costa Izael de Sousa, Piuvezam Grasiela, Medeiros Gidyenne Christine Bandeira Silva de, Maciel Bruna Leal Lima, Morais Ana Heloneida de Araújo
Biochemistry Postgraduate Program, Biosciences Center.
Collective Health Postgraduate Program (PPGSCoL), Center for Health Sciences.
Medicine (Baltimore). 2019 Sep;98(39):e17326. doi: 10.1097/MD.0000000000017326.
Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of hyperglycemia. This study describes a protocol of a systematic review, which analyzes the action of proteins and bioactive peptides of plants in DM2.
The Preferred Reporting Items guide this protocol for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P) was used. The databases that will be used for searching will be PubMed, ScienceDirect, Scopus, Web of Science, EMBASE, and Virtual Health Library, Brazil (VHL). Studies that use bioactive proteins and peptides of vegetal origin in DM2 will be included in the systematic review. The studies will be identified using clinical parameters and the effect on insulin resistance. The characteristics of the studies as control groups, test substance, dosage, intervention time, and the main results will be described. Selection of studies, data extraction, and methodological quality assessment will be performed independently by two experienced reviewers.
This protocol will be the basis for a systematic review identifying the mechanism of action of plant proteins and peptides in type 2 diabetes mellitus.
Systematic reviews from this protocol will provide support for the construction of researches that analyze the effect of plant bioactive proteins and peptides on the control of hyperglycemia and how these molecules act in the control of DM2.
CRD42019110956.
2型糖尿病（DM2）是一种普遍存在的慢性疾病，会导致血糖升高和多种合并症。有证据表明蔬菜中发现的非蛋白质生物活性化合物在控制血糖方面具有作用。本研究描述了一项系统评价方案，该方案分析植物蛋白和生物活性肽在2型糖尿病中的作用。
本方案遵循系统评价和Meta分析方案的首选报告项目（PRISMA-P）指南。将用于检索的数据库包括PubMed、ScienceDirect、Scopus、Web of Science、EMBASE和巴西虚拟健康图书馆（VHL）。在2型糖尿病中使用植物源生物活性蛋白和肽的研究将纳入系统评价。将通过临床参数和对胰岛素抵抗的影响来确定这些研究。将描述研究的特征，如对照组、受试物质、剂量、干预时间和主要结果。研究的筛选、数据提取和方法学质量评估将由两名经验丰富的评审员独立进行。
本方案将作为系统评价的基础，以确定植物蛋白和肽在2型糖尿病中的作用机制。
本方案的系统评价将为开展分析植物生物活性蛋白和肽对血糖控制的影响以及这些分子如何在2型糖尿病控制中发挥作用的研究提供支持。
PROSPERO注册号：CRD42019110956。
