Launders Naomi, Ryan Dermot, Winchester Christopher C, Skinner Derek, Konduru Priyanka Raju, Price David B
Respiratory Effectiveness Group, Cambridge, UK.
Allergy and Respiratory Research Group, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Medical School, Edinburgh EH8 9AG, Scotland.
Pragmat Obs Res. 2019 Sep 23;10:53-65. doi: 10.2147/POR.S211198. eCollection 2019.
In primary care, initial diagnosis of community-acquired pneumonia (CAP) is made on clinical judgment without radiological confirmation or knowledge of the causative organism. Use of CRB65 score has been recommended for assessing the severity of CAP and thereby determining clinical management, but it is not known how frequently these scores are used in primary care.
Primary care consultations in adults with a diagnostic code for CAP between 1 January 2009 and 31 December 2016 were extracted from the Optimum Patient Care Research Database, which at the time of data extraction had over 3.4 million patients in the UK. Episodes without antibiotic prescription on day of diagnosis were excluded, as were records describing past events. Patients admitted to hospital on day of diagnosis were excluded, but were included in exploratory analysis of CRB65 recording.
In total, 4734 episodes of CAP in adults managed in primary care between 1 January 2009 and 31 December 2016 were included. A range of investigations/observations were recorded, including pulse rate (10.7%), chest examinations (9.1%) and blood tests (5.4%). CRB65 scores were recorded in 19 (0.4%) episodes of CAP, 17 of which were after the publication of the NICE guidelines in December 2014. CRB65 recording was no more frequent in 3819 episodes referred to hospital (12, 0.3%; p=0.63), but where recorded, CRB65 scores were higher (Median: 1.0 [interquartile range: 0.5-1.0] vs 2.0 [interquartile range: 1.0-2.0], p=0.04). The most commonly prescribed antibiotic was amoxicillin (40.3%), and 85.9% of episodes had a prescription length of seven days.
CRB65 scores are seldom recorded in UK primary care. Given that these scores are embedded in UK guidelines, further work is required to assess feasibility and barriers to use of CRB65 scores in primary care.
在基层医疗中,社区获得性肺炎(CAP)的初始诊断是基于临床判断,而非影像学确诊或已知致病病原体。推荐使用CRB65评分来评估CAP的严重程度,从而确定临床管理方案,但尚不清楚这些评分在基层医疗中的使用频率。
从最佳患者护理研究数据库中提取2009年1月1日至2016年12月31日期间诊断代码为CAP的成年患者的基层医疗咨询记录,在数据提取时,该数据库在英国有超过340万患者。排除诊断当天未开具抗生素处方的病例,以及描述既往事件的记录。排除诊断当天入院的患者,但将其纳入CRB65记录的探索性分析。
总共纳入了2009年1月1日至2016年12月31日期间在基层医疗中管理的4734例成年CAP病例。记录了一系列检查/观察结果,包括脉搏率(10.7%)、胸部检查(9.1%)和血液检查(5.4%)。19例(0.4%)CAP病例记录了CRB65评分,其中17例是在2014年12月英国国家卫生与临床优化研究所(NICE)指南发布之后。在转诊至医院的3819例病例中,CRB65记录的频率并不更高(12例,0.3%;p = 0.63),但在记录的病例中,CRB65评分更高(中位数:1.0[四分位间距:0.5 - 1.0]对2.0[四分位间距:1.0 - 2.0],p = 0.04)。最常开具的抗生素是阿莫西林(40.3%),85.9%的病例处方时长为7天。
在英国基层医疗中,很少记录CRB65评分。鉴于这些评分已纳入英国指南,需要进一步开展工作来评估在基层医疗中使用CRB65评分的可行性和障碍。