Department of Anatomy, College of Medicine, University of Lagos, Lagos, Nigeria.
R&D Group VitaK, Maastricht University, Maastricht, The Netherlands.
Andrologia. 2019 Nov;51(10):e13416. doi: 10.1111/and.13416. Epub 2019 Oct 1.
Vitamin K is present in the testes though its actual function in male reproduction is poorly understood. This study investigated the harmful effect of extrahepatic vitamin K insufficiency on the testicular structure. Sprague-Dawley rats were fed with a diet containing warfarin for 2, 4 and 8 weeks; control animals received a standard diet without warfarin. It was found that extrahepatic vitamin K deficiency that is induced by warfarin results in histopathological features that range from delayed spermiation, presence of multinucleated giant cells in the seminiferous tubules, germ cells degeneration, asthenozoospermia, oligozoospermia and increase in the percentage of abnormal sperm morphology when compared to the controls. Data obtained from the two groups were analysed using the Student t test. It is concluded that warfarin-induced vitamin K deficiency has a negative impact on spermatogenesis.
维生素 K 存在于睾丸中，但其在男性生殖中的实际功能尚不清楚。本研究调查了肝外维生素 K 不足对睾丸结构的有害影响。Sprague-Dawley 大鼠喂食含有华法林的饮食 2、4 和 8 周；对照动物喂食不含华法林的标准饮食。结果发现，华法林诱导的肝外维生素 K 缺乏导致组织病理学特征，从延迟精子发生、精小管中出现多核巨细胞、生殖细胞退化、弱精症、少精症和畸形精子形态百分比增加，与对照组相比。使用学生 t 检验分析两组数据。结论是，华法林诱导的维生素 K 缺乏对精子发生有负面影响。
