Illei G, Morgan D M
Br J Obstet Gynaecol. 1979 Nov;86(11):878-81. doi: 10.1111/j.1471-0528.1979.tb10715.x.
The existence of a spermine oxidizing enzyme was established in human pregnancy serum by a radiochemical method, and a cross-sectional study of its quantitative profile between 10 and 40 weeks gestation was undertaken. Though there was a wide scatter of values, the rise in the average activity was continuous and highly significant. The flavoprotein inhibitor, quinacrin, inhibited the enzyme activity, while the pyridoxal phosphate inhibitor, isoniazid, had no significant inhibitory effect suggesting that the enzyme is of tissue origin. The possible role of polyamines and their oxidation in physiological immunoregulation is discussed.
通过放射化学方法确定了人妊娠血清中精胺氧化酶的存在，并对妊娠10至40周期间其定量特征进行了横断面研究。尽管数值分布较广，但平均活性的升高是持续且高度显著的。黄素蛋白抑制剂喹吖因抑制酶活性，而磷酸吡哆醛抑制剂异烟肼没有显著抑制作用，这表明该酶源自组织。讨论了多胺及其氧化在生理免疫调节中的可能作用。
