Lee J N, Grudzinskas J G, Chard T
Br J Obstet Gynaecol. 1979 Nov;86(11):888-90. doi: 10.1111/j.1471-0528.1979.tb10717.x.
The concentrations of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), pregnancy specific beta 1 glycoprotein (SP1), ferritin (PP2) and placental protein 5 (PP5) were examined in maternal serum and placental tissue in early and late pregnancy. The circulating concentration of hPL, SP1, and PP5 were higher during late pregnancy than early pregnancy, that of hCG lower, and ferritin (PP2) levels showed no difference. Placental tissue levels of hPL and SP1 were higher in late pregnancy, hCG levels lower, and ferritin (PP2) and PP5 showed no change. The ratio of the concentration in maternal serum to that in placental tissue increased during pregnancy for all proteins with the exception of ferritin. It is proposed that the mechanism of secretion of trophoblast specific proteins varies widely and that this should be taken into account in the clinical interpretation of circulating levels in the mother.
在妊娠早期和晚期，对母血和胎盘组织中的人绒毛膜促性腺激素（hCG）、人胎盘催乳素（hPL）、妊娠特异性β1糖蛋白（SP1）、铁蛋白（PP2）和胎盘蛋白5（PP5）的浓度进行了检测。妊娠晚期hPL、SP1和PP5的循环浓度高于妊娠早期，hCG的浓度低于妊娠早期，铁蛋白（PP2）水平无差异。妊娠晚期胎盘组织中hPL和SP1的水平较高，hCG水平较低，铁蛋白（PP2）和PP5无变化。除铁蛋白外，所有蛋白质在孕期母血与胎盘组织中的浓度比值均升高。有人提出，滋养层特异性蛋白的分泌机制差异很大，在临床解释母亲循环水平时应考虑到这一点。
