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正常男性和不育症患者精液中的胎盘蛋白(人绒毛膜促性腺激素、人胎盘催乳素、妊娠特异性β1-糖蛋白和胎盘蛋白5)。

Placental proteins (human chorionic gonadotropin, human placental lactogen, pregnancy-specific beta 1-glycoprotein, and placental protein 5) in seminal plasma of normal men and patients with infertility.

作者信息

Lee J N, Lian J D, Lee J H, Chard T

出版信息

Fertil Steril. 1983 May;39(5):704-6. doi: 10.1016/s0015-0282(16)47070-6.

DOI:10.1016/s0015-0282(16)47070-6
PMID:6601587
Abstract

Placental proteins, including human chorionic gonadotropin (hCG), human placental lactogen (hPL), pregnancy-specific beta 1-glycoprotein (SP1), and placental protein 5 (PP5) have been detected in human seminal plasma of 20 normal men and 42 patients with infertility. Levels of hPL, SP1, and PP5 were similar in these groups. There were significantly higher levels of hCG in subjects with normal sperm counts than in those with oligospermia or azoospermia. The levels of PP5 in seminal plasma showed an association with sperm motility, suggesting that PP5 may have a significant biologic function in the maintenance of sperm motility.

摘要

在20名正常男性和42名不育患者的人类精浆中检测到了胎盘蛋白,包括人绒毛膜促性腺激素(hCG)、人胎盘催乳素(hPL)、妊娠特异性β1-糖蛋白(SP1)和胎盘蛋白5(PP5)。这些组中hPL、SP1和PP5的水平相似。精子计数正常的受试者的hCG水平显著高于少精子症或无精子症患者。精浆中PP5的水平与精子活力相关,这表明PP5可能在维持精子活力方面具有重要的生物学功能。

相似文献

1
Placental proteins (human chorionic gonadotropin, human placental lactogen, pregnancy-specific beta 1-glycoprotein, and placental protein 5) in seminal plasma of normal men and patients with infertility.正常男性和不育症患者精液中的胎盘蛋白(人绒毛膜促性腺激素、人胎盘催乳素、妊娠特异性β1-糖蛋白和胎盘蛋白5)。
Fertil Steril. 1983 May;39(5):704-6. doi: 10.1016/s0015-0282(16)47070-6.
2
Human seminal plasma contains a wide range of trophoblast-'specific' proteins.人类精浆含有多种滋养层“特异性”蛋白质。
Placenta. 1984 Sep-Oct;5(5):413-7. doi: 10.1016/s0143-4004(84)80021-1.
3
[Clinical significance of pregnancy-specific beta glycoprotein, human placental lactogen and beta-human chorionic gonadotropin in the serum of patients with trophoblastic diseases].[妊娠特异性β-糖蛋白、人胎盘催乳素及β-人绒毛膜促性腺激素在滋养细胞疾病患者血清中的临床意义]
Zhonghua Yi Xue Za Zhi. 1989 Apr;69(4):206-8, 16.
4
[Placental tissue concentration of pregnancy-associated proteins in early and term pregnancies].[早孕期和足月孕期胎盘组织中妊娠相关蛋白的浓度]
Nihon Naibunpi Gakkai Zasshi. 1983 Jul 20;59(7):993-1003. doi: 10.1507/endocrine1927.59.7_993.
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Placental proteins in high-grade urothelial neoplasms. An immunohistochemical study of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta-1-glycoprotein.高级别尿路上皮肿瘤中的胎盘蛋白。人绒毛膜促性腺激素、人胎盘催乳素和妊娠特异性β-1-糖蛋白的免疫组织化学研究。
Cancer. 1989 Jun 15;63(12):2497-504. doi: 10.1002/1097-0142(19890615)63:12<2497::aid-cncr2820631223>3.0.co;2-q.
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Interrelationships of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta 1-glycoprotein throughout normal human gestation.人绒毛膜促性腺激素、人胎盘催乳素和妊娠特异性β1-糖蛋白在正常人类妊娠期的相互关系。
Am J Obstet Gynecol. 1980 Dec 15;138(8):1205-13. doi: 10.1016/s0002-9378(16)32793-4.
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[Immunohistochemical localization of hCG alpha, hCG beta CTP, hPL and SP1 on villous and extravillous trophoblasts in normal human pregnancy].[人正常妊娠时绒毛和绒毛外滋养层细胞中hCGα、hCGβ CTP、hPL和SP1的免疫组织化学定位]
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Jul;39(7):1073-9.
8
Immunolocalization of alpha and beta chains of human chorionic gonadotropin, placental lactogen and pregnancy-specific beta-glycoprotein in term placenta by a touch preparation method.采用触片制备方法对足月胎盘中人绒毛膜促性腺激素α和β链、胎盘催乳素及妊娠特异性β-糖蛋白进行免疫定位。
Histochemistry. 1987;88(1):57-60. doi: 10.1007/BF00490168.
9
Circulating levels of pregnancy proteins in early and late pregnancy in relation to placental tissue concentration.妊娠早期和晚期循环中妊娠蛋白水平与胎盘组织浓度的关系。
Br J Obstet Gynaecol. 1979 Nov;86(11):888-90. doi: 10.1111/j.1471-0528.1979.tb10717.x.
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Human chorionic gonadotropin beta-subunit in human semen.人类精液中的人绒毛膜促性腺激素β亚基
Arch Androl. 1988;20(1):87-99. doi: 10.3109/01485018808987057.

引用本文的文献

1
Activation of motility and chemotaxis in the spermatozoa: From invertebrates to humans.精子运动性和趋化性的激活:从无脊椎动物到人类。
Reprod Med Biol. 2005 May 3;4(2):101-114. doi: 10.1111/j.1447-0578.2005.00099.x. eCollection 2005 Jun.
2
Decreased levels of genuine large free hCG alpha in men presenting with abnormal semen analysis.男性精液分析异常时,真的大游离 hCGα 水平降低。
Reprod Biol Endocrinol. 2011 Aug 12;9:114. doi: 10.1186/1477-7827-9-114.