Sistani Sharareh Sanei, Moghtaderi Ali, Dashipoor Ali Reza, Ghaffarpoor Maryam, Ghahderijani Bahareh Heshmat
Department of Radiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Neurology, Zahedan University of Medical Sciences, Zahedan, Iran.
Eur J Transl Myol. 2019 Aug 8;29(3):8361. doi: 10.4081/ejtm.2019.8361. eCollection 2019 Aug 2.
An increasing body of evidence suggests that low vitamin D (25-[OH]-D) concentrations is linked to increased activity in multiple sclerosis (MS) patients and MS relapse. Therefore, the current study was aimed to evaluate vitamin D serum concentrations and its possible seasonal variations among MS patients with relapse. This prospective, descriptive study was conducted on patients with MS relapse who referred to the neurology center of Ali ibn Abi Talib Hospital in Zahedan during one year. Magnetic Resonance Imaging (MRI)-Spine was performed for 90 patients and serum samples were collected from patient to measure serum vitamin D levels using RIA KIT. Furthermore, the plaques in each patient's MRI were counted and then recorded. Descriptive and inductive statistics were conducted using statistical software. Our findings indicated a significant correlation between serum vitamin D level and cervical spinal cord plaques (p = 0.007, r = 0.28), while no association was revealed between serum vitamin D level and number of brain plaque. Furthermore, a significant association was also observed between number of cervical spinal cord plaques and serum vitamin D levels. In addition, a reverse correlation was observed between number of cervical spinal cord plaques and serum vitamin D levels in spring. In autumn, there was a statistically significant relationship between number of brain plaque and serum vitamin D level. Additionally, a statistically significant relationship was found between serum vitamin D levels and number of plaques in winter. Our findings are in agreement with some previous studies that reported conflicting result, where the association of season with the prevalence of relapse cases cannot be verified. Although the mean serum levels of vitamin D are inversely correlated with the incidence of relapses in winter. However, the values obtained in the spring do not confirm such an inverse relationship.
越来越多的证据表明，低维生素D（25-羟维生素D）浓度与多发性硬化症（MS）患者的活动增加及MS复发有关。因此，本研究旨在评估复发型MS患者的血清维生素D浓度及其可能的季节性变化。本前瞻性描述性研究针对一年内转诊至扎黑丹阿里·伊本·阿比·塔利卜医院神经科中心的复发型MS患者进行。对90例患者进行了脊柱磁共振成像（MRI）检查，并采集患者血清样本，使用放射免疫分析试剂盒测量血清维生素D水平。此外，对每位患者MRI中的斑块进行计数并记录。使用统计软件进行描述性和归纳性统计分析。我们的研究结果表明，血清维生素D水平与颈髓斑块之间存在显著相关性（p = 0.007，r = 0.28），而血清维生素D水平与脑斑块数量之间未显示出相关性。此外，颈髓斑块数量与血清维生素D水平之间也存在显著关联。另外，春季颈髓斑块数量与血清维生素D水平呈负相关。秋季，脑斑块数量与血清维生素D水平之间存在统计学显著关系。此外，冬季血清维生素D水平与斑块数量之间也存在统计学显著关系。我们的研究结果与之前一些报道结果相互矛盾的研究一致，即季节与复发病例患病率之间的关联无法得到证实。尽管冬季维生素D的平均血清水平与复发率呈负相关。然而，春季获得的值并未证实这种负相关关系。
