Lapina D B, Gabrielian N D, Khorlin A Ia
Biokhimiia. 1979 Sep;44(9):1648-56.
It was demonstrated that microsomal membranes from frog liver contain at least two different sialyltransferases involved in the synthesis of alpha 2 leads to 3 and alpha 2 leads to 6 oligosaccharide isomers. Studies on acceptor specificity of the sialyltransferase system with respect to low molecular acceptors revealed its similarity to the mammalian sialyltransferase system. However, sharp distinctions were observed in sialylation of mammalian glycoproteins. It was assumed that that the disaccharide unit of the acceptor oligosaccharide chain is a structural element, which in necessary but not sufficient for glycoprotein recognition by sialyltransferases.
已证明，蛙肝微粒体膜含有至少两种不同的唾液酸转移酶，它们参与α2→3和α2→6寡糖异构体的合成。关于唾液酸转移酶系统对低分子受体的受体特异性研究表明，它与哺乳动物唾液酸转移酶系统相似。然而，在哺乳动物糖蛋白的唾液酸化过程中观察到了明显的差异。据推测，受体寡糖链的二糖单元是一种结构元件，它对于唾液酸转移酶识别糖蛋白是必要的，但并不充分。
