评估中性粒细胞与淋巴细胞比值在预测血流感染中的作用。
Evaluation of neutrophil-lymphocyte ratio in predicting bloodstream infection.
作者信息
Qu Jian, Yuan Hai-Yan, Huang Ying, Qu Qiang, Ou-Yang Zhan-Bo, Li Guo-Hua, Zhu Hai-Hong, Lu Qiong
机构信息
Department of Pharmacy, The Second Xiangya Hospital, Central South University; Institute of Clinical Pharmacy, Central South University, Changsha 410011, PR China.
Department of Pharmacy, College of Pharmacy, Central South University, Changsha 410011, PR China.
出版信息
Biomark Med. 2019 Oct;13(15):1255-1261. doi: 10.2217/bmm-2018-0253. Epub 2019 Oct 3.
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in bloodstream infection (BSI) deserves further investigation. The NLR values were measured and compared in BSI patients and healthy controls. The receiver operating characteristic of NLR and cut-off values were measured in BSI patients and subgroups. We have measured the NLR of study group with 2160 BSI patients and normal group with 2523 healthy controls, which was significantly high in study group (11.36 ± 21.38 vs 2.53 ± 0.86; p < 0.001) and the area under the curve was 0.834 (95% CI: 0.825-0.842; p < 0.001). The critical value of NLR for diagnosis of BSI was 3.09, with a sensitivity of 75.3%, and a specificity of 93.6%. NLR is an effective diagnostic indicator of including BSIs of Gram-negative bacteria, Gram-positive bacteria and fungus.
中性粒细胞与淋巴细胞比值（NLR）在血流感染（BSI）中的预后作用值得进一步研究。对BSI患者和健康对照者的NLR值进行了测量和比较。在BSI患者及其亚组中测量了NLR的受试者工作特征曲线及临界值。我们测量了2160例BSI患者的研究组和2523例健康对照者的正常组的NLR，研究组的NLR显著更高（11.36±21.38对2.53±0.86；p<0.001），曲线下面积为0.834（95%CI：0.825 - 0.842；p<0.001）。诊断BSI的NLR临界值为3.09，敏感性为75.3%，特异性为93.6%。NLR是包括革兰氏阴性菌、革兰氏阳性菌和真菌引起的BSIs的有效诊断指标。
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