Zähringer J, Pritzl N, Stäb G, Kreuzer E
Adv Myocardiol. 1985;6:285-95.
A method has been developed that allows the direct quantitation of cardiac messenger RNA in heart-muscle biopsies. This provides a new tool to directly assess changes in cardiac gene expression in cardiac biopsies. Using this method, we have analyzed changes in cardiac gene expression during induction and regression of triiodothyronine-induced heart hypertrophy, during development of heart atrophy secondary to starvation and protein depletion, in adriamycin cardiomyopathy, and in patients with mitral-valve diseases.
已经开发出一种方法，可直接对心肌活检中的心脏信使核糖核酸进行定量。这为直接评估心脏活检中心脏基因表达的变化提供了一种新工具。使用这种方法，我们分析了三碘甲状腺原氨酸诱导的心脏肥大的诱导和消退过程、饥饿和蛋白质消耗继发的心脏萎缩发展过程、阿霉素性心肌病以及二尖瓣疾病患者心脏基因表达的变化。
