Chongqing Key Laboratory of Traditional Chinese Medicine to Prevent and Treat Autoimmune Diseases, Chongqing, P.R. China.
Department of Pathology, Xinqiao Hospital, Army Medical University, Chongqing, P.R. China.
DNA Cell Biol. 2019 Nov;38(11):1178-1187. doi: 10.1089/dna.2019.4852. Epub 2019 Oct 3.
proline-glutamic acid (PE)/proline-proline-glutamic acid (PPE) family proteins, with >160 members, are crucial for virulence, cell wall, host cell fate, host Th1/Th2 balance, and CD8 T cell recognition. Ca signaling is involved in PE/PPE protein-mediated host-pathogen interaction. PE/PPE proteins also function in heme utilization and nitric oxide production. PE/PPE family proteins are intensively pursued as diagnosis biomarkers and vaccine components.
脯氨酸-谷氨酸（PE）/脯氨酸-脯氨酸-谷氨酸（PPE）家族蛋白，超过 160 个成员，对毒力、细胞壁、宿主细胞命运、宿主 Th1/Th2 平衡和 CD8 T 细胞识别至关重要。钙信号参与 PE/PPE 蛋白介导的宿主-病原体相互作用。PE/PPE 蛋白还参与血红素利用和一氧化氮产生。PE/PPE 家族蛋白被广泛研究作为诊断生物标志物和疫苗成分。
