ICMR-National Institute of Pathology, Ansari Nagar West, New Delhi 110029, India.
Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi 110016, India.
Int J Mol Sci. 2022 Jan 4;23(1):525. doi: 10.3390/ijms23010525.
() is a successful pathogen that can reside within the alveolar macrophages of the host and can survive in a latent stage. The pathogen has evolved and developed multiple strategies to resist the host immune responses. escapes from host macrophage through evasion or subversion of immune effector functions. genome codes for PE/PPE/PE_PGRS proteins, which are intrinsically disordered, redundant and antigenic in nature. These proteins perform multiple functions that intensify the virulence competence of majorly by modulating immune responses, thereby affecting immune mediated clearance of the pathogen. The highly repetitive, redundant and antigenic nature of PE/PPE/PE_PGRS proteins provide a critical edge over other proteins in terms of imparting a higher level of virulence and also as a decoy molecule that masks the effect of effector molecules, thereby modulating immuno-surveillance. An understanding of how these proteins subvert the host immunological machinery may add to the current knowledge about virulence and pathogenesis. This can help in redirecting our strategies for tackling infections.
潜伏结核分枝杆菌是一种成功的病原体，可以存在于宿主的肺泡巨噬细胞中，并处于潜伏状态。该病原体已经进化和发展出多种策略来抵抗宿主的免疫反应。通过逃避或颠覆免疫效应功能，潜伏结核分枝杆菌从宿主巨噬细胞中逃逸。其基因组编码 PE/PPE/PE_PGRS 蛋白，这些蛋白本质上是无序的、冗余的和抗原性的。这些蛋白具有多种功能，通过调节免疫反应，从而影响免疫介导的病原体清除，从而增强结核分枝杆菌的毒力。PE/PPE/PE_PGRS 蛋白的高度重复、冗余和抗原性在赋予更高水平的毒力方面优于其他蛋白，并且作为一种诱饵分子，掩盖了效应分子的作用，从而调节免疫监视。了解这些蛋白如何颠覆宿主的免疫机制，可以增加我们对结核分枝杆菌毒力和发病机制的现有认识。这有助于重新调整我们应对结核分枝杆菌感染的策略。
