Sun Zejia, Li Xin, Zheng Xiang, Cao Peng, Yu Baozhong, Wang Wei
Institute of Urology, Capital Medical University, Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Beijing, China.
J Int Med Res. 2019 Nov;47(11):5426-5440. doi: 10.1177/0300060519876138. Epub 2019 Oct 3.
Stem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem cell mobilization. This review describes the important role of SDF-1 in tissue injury and how it works in tissue revascularization and regeneration via CXCR4. Furthermore, factors influencing the SDF-1/CXCR4 axis and its clinical potential in ischaemia reperfusion injury, such as renal transplantation, are discussed. Exploring signalling pathways of the SDF-1/CXCR4 axis will contribute to the development of stem cell therapy so that more clinical problems can be solved. Controlling directional homing of stem cells through the SDF-1/CXCR4 axis is key to improving the efficacy of stem cell therapy for tissue injury. CXCR4 antagonists may also be effective in increasing circulating levels of adult stem cells, thereby exerting beneficial effects on damaged or inflamed tissues in diseases that are currently not treated by standard approaches.
干细胞疗法在治疗多种病症方面已显示出前景，如心肌梗死、缺血性中风和器官移植。基质细胞衍生因子-1（SDF-1）/CXC趋化因子受体-4（CXCR4）轴在干细胞动员中起关键作用。本综述描述了SDF-1在组织损伤中的重要作用，以及它如何通过CXCR4在组织血管再生和修复中发挥作用。此外，还讨论了影响SDF-1/CXCR4轴的因素及其在缺血再灌注损伤（如肾移植）中的临床潜力。探索SDF-1/CXCR4轴的信号通路将有助于干细胞疗法的发展，从而解决更多临床问题。通过SDF-1/CXCR4轴控制干细胞的定向归巢是提高干细胞疗法治疗组织损伤疗效的关键。CXCR4拮抗剂在提高成体干细胞循环水平方面可能也有效，从而对目前尚无标准治疗方法的疾病中受损或发炎的组织产生有益影响。
