Schneider J F, Thomas H E, McNamara P M, Kannel W B
Am J Cardiol. 1985 May 1;55(11):1332-8. doi: 10.1016/0002-9149(85)90499-0.
To determine whether any associated electrocardiographic findings in persons with newly acquired complete left bundle branch block (LBBB) correlate with the prevalence of associated clinically apparent cardiovascular abnormalities, electrocardiograms (ECGs) from all 55 members of the Framingham Study cohort in whom LBBB developed during 18 years of routine prospective biennial examinations were reviewed. A QRS axis left of or equal to 0 degrees, left atrial conduction delay and an inverted T wave in lead V6 on the first ECG with LBBB, and an abnormal ECG in the Framingham examination preceding the appearance of LBBB each correlated with the prevalence of systemic hypertension, cardiomegaly, coronary heart disease and congestive heart failure. However, neither the PR interval nor the duration of the QRS complex on the first ECG with LBBB correlated with the prevalence of any of the associated cardiovascular abnormalities. The 8 patients with neither left atrial conduction delay nor a QRS axis left of or equal to 0 degrees on the first Framingham ECG with LBBB nor an abnormal ECG on the examination preceding the appearance of LBBB were 6 times more likely to remain free of all of the clinical cardiovascular abnormalities than the 47 patients with 1 or more of these 3 electrocardiographic findings (p less than 0.001).
为了确定新发生的完全性左束支传导阻滞（LBBB）患者的相关心电图表现是否与相关临床明显心血管异常的患病率相关，我们回顾了弗雷明汉姆研究队列中在18年常规前瞻性两年一次检查期间发生LBBB的所有55名成员的心电图（ECG）。LBBB首次心电图上QRS轴位于0度或0度左侧、左心房传导延迟、V6导联T波倒置，以及LBBB出现之前的弗雷明汉姆检查中的异常心电图，均与系统性高血压、心脏扩大、冠心病和充血性心力衰竭的患病率相关。然而，LBBB首次心电图上的PR间期和QRS波群时限均与任何相关心血管异常的患病率无关。在弗雷明汉姆首次LBBB心电图上既无左心房传导延迟、QRS轴位于0度或0度左侧，也无LBBB出现之前检查中的异常心电图的8例患者，无所有临床心血管异常的可能性是有这三种心电图表现中1种或更多种表现的47例患者的6倍（p<0.001）。
