Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Department of Animal Sciences, College of Animal Sciences and Technologies, Northwest A&F University, Yangling, Shaanxi 712100, China.
Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
Animal. 2020 Feb;14(2):312-321. doi: 10.1017/S175173111900209X. Epub 2019 Oct 4.
In the livestock industry, subcutaneous and visceral fat pads are considered as wastes, while intramuscular fat or marbling fat is essential for improving flavor and palatability of meat. Thus, strategies for optimizing fat deposition are needed. Intramuscular adipocytes provide sites for lipid deposition and marbling formation. In the present article, we addressed the origin and markers of intramuscular adipocyte progenitors - fibro-adipogenic progenitors (FAPs), as well as the latest progresses in mechanisms regulating the proliferation and differentiation of intramuscular FAPs. Finally, by targeting intramuscular FAPs, possible nutritional manipulations to improve marbling fat deposition are discussed. Despite recent progresses, the properties and regulation of intramuscular FAPs in livestock remain poorly understood and deserve further investigation.
在畜牧业中，皮下和内脏脂肪垫被认为是废物，而肌内脂肪或大理石纹脂肪则是改善肉质口感和可接受性的关键。因此，需要优化脂肪沉积的策略。肌内脂肪细胞为脂质沉积和大理石纹形成提供了场所。在本文中，我们探讨了肌内脂肪细胞祖细胞——纤维脂肪祖细胞（FAP）的起源和标记物，以及调节肌内 FAP 增殖和分化的最新机制进展。最后，通过针对肌内 FAP，讨论了改善大理石纹脂肪沉积的潜在营养干预措施。尽管取得了一些进展，但家畜肌内 FAP 的特性和调控仍知之甚少，值得进一步研究。
