Pharmacogenomics, Mark R. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, 2650 Ridge Avenue, Evanston, IL 60201, USA.
Department of Family Medicine, NorthShore University HealthSystem, 6810 North McCormick Boulevard, Lincolnwood, IL 60712, USA.
Med Clin North Am. 2019 Nov;103(6):977-990. doi: 10.1016/j.mcna.2019.07.002. Epub 2019 Aug 24.
Pharmacogenomics (PGx) is a powerful tool that can predict increased risks of adverse effects and sub-therapeutic response to medications. This article establishes the core principles necessary for a primary care provider to meaningfully and prudently use PGx testing. Key topics include in which patients PGx testing should be considered, how PGx tests are ordered, how the results are translated into clinical recommendations, and what further advancements are likely in the near future. This will provide clinicians with a foundational knowledge of PGx that can allow incorporation of this tool into their practice or support further personal investigation.
药物基因组学（PGx）是一种强大的工具，可以预测药物不良反应风险增加和治疗效果不佳的情况。本文确定了初级保健提供者有意义且谨慎地使用 PGx 检测所需的核心原则。关键主题包括哪些患者应考虑进行 PGx 检测、如何订购 PGx 测试、如何将结果转化为临床建议，以及未来可能会有哪些进一步的进展。这将为临床医生提供 PGx 的基础知识，使他们能够将这一工具纳入他们的实践或支持进一步的个人研究。
