Tarazi R C, Fouad F M
Annu Rev Med. 1985;36:407-14. doi: 10.1146/annurev.me.36.020185.002203.
Reversal of left ventricular hypertrophy in hypertensive patients has been proven to follow effective blood pressure control by some antihypertensive drugs. This reversal does not depend solely on the degree of pressure reduction but is also modulated by other factors including, among others, stability of blood pressure control, degree of cardioadrenergic stimulation, and individual variations due to genetic background and possible age. Regression of left ventricular hypertrophy is most likely to occur when the reduction in arterial pressure and peripheral resistance can be maintained without induced reflex cardiac stimulation. Left ventricular performance at rest was not depressed by the reduction in cardiac mass but remained normal both in absolute terms and in relation to changes in LV end-systolic stress.
已证实，高血压患者左心室肥厚的逆转可通过某些抗高血压药物有效控制血压来实现。这种逆转不仅取决于血压降低的程度，还受到其他因素的调节，其中包括血压控制的稳定性、心脏肾上腺素能刺激的程度以及遗传背景和可能的年龄导致的个体差异。当动脉压和外周阻力降低而不引起反射性心脏刺激时，左心室肥厚最有可能发生逆转。静息时左心室功能并未因心脏质量减轻而降低，无论是绝对值还是相对于左心室收缩末期压力的变化，均保持正常。
