Odularu Ayodele T, Ajibade Peter A, Mbese Johannes Z
Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.
School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg Campus, Scottsville 3209, South Africa.
Bioinorg Chem Appl. 2019 Sep 10;2019:6416198. doi: 10.1155/2019/6416198. eCollection 2019.
The aim of this mini review was to report the molybdenum compound intervention to control cancer disease. The intervention explains its roles and progress from inorganic molybdenum compounds via organomolybdenum complexes to its nanoparticles to control oesophageal cancer and breast cancer as case studies. Main contributions of molybdenum compounds as anticancer agents could be observed in their nanofibrous support with suitable physicochemical properties, combination therapy, and biosensors (biomarkers). Recent areas in anticancer drug design, which entail the uses of selected targets, were also surveyed and proposed.
本综述的目的是报告钼化合物在控制癌症方面的干预作用。该干预阐述了其从无机钼化合物经有机钼配合物到其纳米颗粒在控制食管癌和乳腺癌方面的作用及进展,并以此作为案例研究。钼化合物作为抗癌剂的主要贡献体现在其具有合适理化性质的纳米纤维载体、联合治疗以及生物传感器(生物标志物)方面。本文还对抗癌药物设计中涉及选定靶点应用的最新领域进行了调查并提出了建议。