Slowikowski D L, Schram K H
Biomed Mass Spectrom. 1985 Feb;12(2):72-8. doi: 10.1002/bms.1200120205.
The fast atom bombardment (FAB) mass spectra of bouvardin (1) 6-O-methylbouvardin (2), deoxybouvardin (3) and a synthetic analog (4) have been examined. The spectra of the bicyclic compounds 1-3 display site-directed fragmentations resulting from the presence of a phenolic bridged tyrosine moiety unique to this class of compounds. Comparison of the spectrum of 4, which lacks the rigid 14-membered ring, with the spectra of 1-3 shows some similarities, but clearly does not cleave in a site-directed manner as the other bouvardin analogs. Fragmentation pathways are postulated which account for most of the major ions observed in the FAB mass spectra of these potentially useful antitumor agents. Metastable ion analysis confirms the operation of the proposed pathways.
已对波伐定（1）、6 - O - 甲基波伐定（2）、脱氧波伐定（3）及一种合成类似物（4）的快原子轰击（FAB）质谱进行了研究。双环化合物1 - 3的质谱显示出定点裂解，这是由于这类化合物特有的酚桥连酪氨酸部分的存在所致。将缺乏刚性14元环的4的质谱与1 - 3的质谱进行比较，结果显示出一些相似性，但显然不像其他波伐定类似物那样以定点方式裂解。推测了裂解途径，这些途径解释了在这些潜在有用的抗肿瘤药物的FAB质谱中观察到的大多数主要离子。亚稳离子分析证实了所提出途径的运行情况。
